|From the microbe engineer's petri dishes into your guts. It's not unlikely that we are about to see "anti-obesity" bacteria being sold in a year or two.|
The principle appears to be hilariously simple. The scientists "manufactured" a type of E. coli Nissle bacteria (1917), that produces so-called N-acylphosphatidylethanolamines (NAPEs). These "NAPEs" are precursors to the N-acylethanolamide (NAE) family of lipids, which are synthesized in the small intestine in response to feeding and reduce food intake and obesity.
The Consequence: Well, you just have to take a closer look at the data in Figure 1 to see that the provision of these bacteria in the drinking did more than just prevent the rodent-typical fat gain on a high fat diet.
|Figure 1: Weight gain (g) and fat mass (g) in rodents on high fat diet, with water, placebo (vehicle), regular E. coli (pEcN) and NAPE-produce E.coli in the drinking water (Chen. 2014)|