|CLA - A muscle specific glucose repartitioner for lean & athletic individuals?|
Interestingly, Farina et al. also found that the beneficial effects of CLA were significantly more pronounced and without significant side effects in rodents who had been deprived of all omega-6 fatty acids - including CLA - before.
Unfortunately, the provision of conjugated linoleic acid did also have negative effects on some aspects of glucose control. For example, Farina et al. observed a significant reduction in insulin response capacity that may - in the long run - compromise their ability to handle glucose.
|Figure 2: Glycogen levels (a) and differences (b) in vastus lateralis of human skeletal muscle after a single bout of exercise in CLA and placebo trials (Tsao. 2014)|
|Figure 3: GLUT4 protein level (a) and P-Akt/Akt ratio (b) in vastus lateralis of human skeletal muscle after a single bout of exercise in CLA and placebo trials (Tsao. 2014).|
- Fariña, Ana C., et al. "Conjugated linoleic acid improves glucose utilization in the soleus muscle of rats fed linoleic acid–enriched and linoleic acid–deprived diets." Nutrition Research (2014).
- Perez-Matute, P., et al. "Conjugated linoleic acid inhibits glucose metabolism, leptin and adiponectin secretion in primary cultured rat adipocytes." Molecular and cellular endocrinology 268.1 (2007): 50-58.
- Ritsche, Kevin, et al. "Acute Exercise-Induced Growth Hormone is Attenuated in Response to Short-Term, High-Intensity Exercise Training." (2014).
- Tsao, Jung-Piao, et al. "Oral conjugated linoleic acid supplementation enhanced glycogen resynthesis in exercised human skeletal muscle." Journal of sports sciences ahead-of-print (2014): 1-9.