tag:blogger.com,1999:blog-44472491235196583472024-03-16T08:08:59.659+01:00SuppVersity - Nutrition and Exercise Science for EveryoneWhere BRO- and PRO-Science Unite in the Spirit of True WisdomAdel Moussahttp://www.blogger.com/profile/11282066708304898697noreply@blogger.comBlogger1619999tag:blogger.com,1999:blog-4447249123519658347.post-38416043635003191362015-07-28T16:23:00.000+02:002015-07-28T16:33:19.827+02:00ALA, Berberine, Metformin, Resveratrol, AICAR & Co - Are AMPK Mimetics & Activators Good or Bad for Athletes?
Unless you're planning to just sit, instead of cycle on your spinning bike, it is by no means sure if your performance well benefit or maybe even suffer from the use of AMPK mimetics and activators.
Recently someone asked me on Facebook, whether AMPK activators like Lipoic acid (ALA), Berberine, Metformin, AICAR & Co wouldn't make excellent performance boosters. I pondered that Adel Moussahttp://www.blogger.com/profile/11282066708304898697noreply@blogger.comtag:blogger.com,1999:blog-4447249123519658347.post-49837761908985675792013-04-14T16:13:00.001+02:002013-04-23T18:56:00.895+02:00Fighting to Stay Lean? These 20+ Anti-Obesity Agents Have the Potential to Inhibit Fat Gain Right at the Cellular Level
No, none of the 20 agents in the list below is going to do the work for you, but they could help you "conserve" the results, keep you lean on a bulk and/or avoid the hazardous Yoyo effect when you go off a die.
It's actually normal that the introduction is the last part of an article I write. What's special about today's SuppVersity article is thus not that I write the introduction at the endAdel Moussahttp://www.blogger.com/profile/11282066708304898697noreply@blogger.comtag:blogger.com,1999:blog-4447249123519658347.post-63690882384594061502012-12-21T18:30:00.002+01:002012-12-21T18:32:26.493+01:00Science Round-Up Seconds: Follow-Up on Gum Arabic for Fat Loss. DMAA or Schizandra, Which Caused a Stroke in a Young Soldier? Low Doses of Resveratrol Better Than High Ones? Vitamin E Keeps Diabetic Brains Intact.
When it's served like this, Gum Arabic looks more like a healthy snack than a weight loss adjuvant.
I guess everyone who has already listened to the podcast of yesterday's show or was even able to listen live, will have noticed that the audio quality - yet not my German accent - have improved significantly, now that Carl and I did eventually switch to Skype instead of the landline. I know, Adel Moussahttp://www.blogger.com/profile/11282066708304898697noreply@blogger.comtag:blogger.com,1999:blog-4447249123519658347.post-52068823841056667492012-08-27T16:37:00.000+02:002012-09-08T06:30:34.955+02:00Leucine + Resveratrol - Synergistic Sirtuin Boosters: +118% Fatty Acid Oxidation, 60% Increase In Muscular Glucose Uptake, -30% Visceral Fat & More - To Good to be True?
Image 1: Can you really team up leucine (or HMB) and resveratrol to make tired mitochondria get a move on? NuSirt Sciences says "YES!" And in the dish and rodents it's actually already working.
What happens if you marry a well-known AMPK promoter and exercise mimetic, with an even more prominent exercise adjuvant and nutritional mTOR booster? Will they neutralize each other? Think about it....Adel Moussahttp://www.blogger.com/profile/11282066708304898697noreply@blogger.comtag:blogger.com,1999:blog-4447249123519658347.post-19585807133406385672012-07-20T17:41:00.001+02:002012-07-20T17:41:57.932+02:00Build a Bigger Mitochondrial Engine and Double Your Endurance With Chitooligosaccharides! Glucosamine Mix from Chitosan Acts on Sirt1 & AMPK, Similar to Resveratrol
Figure 1: Glucosamine composition of the chitooligosaccharide used in the study (data adapted from Jeong. 2012).
Usually I try to avoid this term, as it seems to imply that there is, or at least soon will be a pill that would allow you to stay the lazy bastard you are now and still make it into your old age, healthy lean, attractive and vigorous, but in this case the word "exercise mimetic" isAdel Moussahttp://www.blogger.com/profile/11282066708304898697noreply@blogger.comtag:blogger.com,1999:blog-4447249123519658347.post-48932610021969188892012-06-24T16:54:00.001+02:002012-06-24T16:54:39.886+02:00Resveratrol from 100l of 1994 Pinot Noir Could Increase Fat Oxidation by 71%, Strength by 18-58% and Endurance by 20% - At Least, If You Could Afford and Drink It Every Day!
Image 1: Itadori (Japanese Knotweed) and selected varieties of red wine are the best yet vastly 'underdosed' sources of resveratrol (see red box, below)
At least in rodents, resveratrol, the red-wine polyphenol, has been shown to act as an exercise mimetic, exerting profound effects on PGC-alpha expression which protect muscle from wasting due to mechanical unloading (also know as extreme Adel Moussahttp://www.blogger.com/profile/11282066708304898697noreply@blogger.comtag:blogger.com,1999:blog-4447249123519658347.post-76310817188628019712011-07-13T08:42:00.007+02:002011-07-13T13:11:41.677+02:00Mitochondrial Proanthocyanidin-Tuning: Fruit & Seed Extracts from Grapes Cheer Up Tired Mitochondria.
Image 1: Grapes - mitochondrial super food.
While I am still not sold on the idea that the unfortunate and unhealthy fate of being a fat slob is in your genes, it is a commonly accepted scientific fact that lifestyle factors (and thus epigenetics) contribute to obesity related mitochondrial dysfunctions. Defective cellular powerplants, on the other hand, make it increasingly Adel Moussahttp://www.blogger.com/profile/11282066708304898697noreply@blogger.comtag:blogger.com,1999:blog-4447249123519658347.post-58384609189801824802011-06-09T07:27:00.001+02:002011-06-09T07:42:46.912+02:00Mitochondrial Super Food: R-ALA, Acetyl-L-Carnitine, Biotin, Nicotinamide (B3), Riboflavin (B2), Pyridoxine (B6), Creatine, CoQ10, Resveratrol & Taurine Optimize Mitochondrial Function.From China, the biggest (and cheapest) producer of raw materials for dietary supplements comes a study (Sun. 2011) on the effectiveness of a mitochondrial nutrient combination on performance and mitochondrial biogenesis in exhaustively exercised rats, which may well have consequences on the number of items on your next supplement shopping list.
For 4 weeks, Sun et al. Adel Moussahttp://www.blogger.com/profile/11282066708304898697noreply@blogger.comtag:blogger.com,1999:blog-4447249123519658347.post-12117161011182013072011-06-08T07:49:00.000+02:002011-06-08T07:49:14.965+02:00Resveratrol Attenuates Insulin Resistance - Now, We Know Why: Grape Skin Polyphenol Ameliorates Intramuscular Fat Deposition and Improves Mitochondrial β-oxidation in Rats on a High Fat Diet.
Image 1: Grapes - sugary super food
and source of resveratrol.
Despite the literal "flood" of studies on the myriad of effects high doses of the grape polyphenol, resveratrol, have on isolated cell cultures; little is known about the mechanism behind its ameliorative effect on various symptoms of the metabolic syndrome. Now, a recent study (Chen. 2011) from the Department ofAdel Moussahttp://www.blogger.com/profile/11282066708304898697noreply@blogger.comtag:blogger.com,1999:blog-4447249123519658347.post-78893654225252244052011-05-10T02:35:00.001+02:002011-05-10T02:35:00.233+02:00Resveratrol For Fat Loss: Scientists Uncover Underlying Mechanism - Increase in ATGL Gene and Protein ExpressionMaybe you have been wondering that I am posting relatively little information about the stilbenoid resveratrol. And you may also be surprised to hear that this is not despite, but rather because the grape polyphenol is among the current favorites of each and every lab-coated petri-dish attendant, who either has or is just in the process of obtaining his PhD. There is a massive amount of Adel Moussahttp://www.blogger.com/profile/11282066708304898697noreply@blogger.comtag:blogger.com,1999:blog-4447249123519658347.post-32210064647473744092011-03-05T03:13:00.001+01:002011-03-05T03:13:00.156+01:00Heart Protective Effect of Red Wine not Exclusively Due to Resveratrol. Melatonin Potentially the Major Player!Resveratrol, the red wine polephynol still is in everyone's mouth (literally, as well as metaphorically), yet a recent (Lamont. 2011) study published in the Journal of Pineal Research indicates that another hitherto overlooked constituent of the fermented grape juice factors into its protective value: Melatonin.
Lamont et al. found that, at the doses which can be found in red wine, naturally, Adel Moussahttp://www.blogger.com/profile/11282066708304898697noreply@blogger.comtag:blogger.com,1999:blog-4447249123519658347.post-7645903255546170282011-01-31T03:26:00.001+01:002011-01-31T07:17:00.714+01:00Resveratrol Increases Lipolysis and Reduces Lipogenesis in Mature AdipocytesIf you are (as I hope) an avid reader and daily visitor of the SuppVersity, you probably remember Friday's news on the "Side Effects of Polyphenol Supplementation". I just hope you did not throw away all your supplements immediately, because eventually the question of side effects is always relative. If, for example, you are a sumo competitor and in dire need of gaining mass, no matter what. It Adel Moussahttp://www.blogger.com/profile/11282066708304898697noreply@blogger.comtag:blogger.com,1999:blog-4447249123519658347.post-53665325120695509022011-01-28T03:25:00.007+01:002011-01-28T07:29:06.648+01:00Unexpected Side Effects of Flavonoid Supplementation: Do You have to Re-Evaluate the Use of EGCG, Grape Seed Extract & Co?It is pretty exciting to see how scientists find new beneficial constituents in common foods on a daily basis. A group of these phytoprotectants is called "flavonoids". Respective extracts from grapes, green tea, etc. have been shown to exhibit various health benefits and supplement companies make a fortune selling them to health-conscious costumers. The question however remains: Did nature Adel Moussahttp://www.blogger.com/profile/11282066708304898697noreply@blogger.comtag:blogger.com,1999:blog-4447249123519658347.post-69231341923250766102011-01-25T03:36:00.000+01:002011-01-25T03:36:00.508+01:00Resveratrol Fails to Ameliorate inflammatory response and Delayed Onset Muscle Soreness After a MarathonResveratrol, an antioxidant polyphenol from the skin of red grapes, has now been around for quite a while and as it was in the case of almost every other antioxidant which was hailed as a powerful panaceum (e.g. vitamin E) it slowly transpires that the real life value of resveratrol may well fall short of the expectations its potency in (mostly) in vitro studies rose among scientists and laymen Adel Moussahttp://www.blogger.com/profile/11282066708304898697noreply@blogger.comtag:blogger.com,1999:blog-4447249123519658347.post-70020939359113108902010-12-07T03:10:00.003+01:002010-12-07T08:00:22.809+01:00Opposing Effects of Resveratrol Depend on DosageWhile the hype about resveratrol appears to be over, it is still one of the cornerstones of many people seeking to improve health or promote longevity. If you belong to this group of people, you might find it interesting that without proper dosing, resveratrol may in fact do the exact opposite of what you were paying for.
A recent review published in Human and Experimental Toxicology (Calabrese.Adel Moussahttp://www.blogger.com/profile/11282066708304898697noreply@blogger.comtag:blogger.com,1999:blog-4447249123519658347.post-34989986518863473992010-07-17T20:00:00.015+02:002010-07-18T14:22:30.852+02:00Resveratrol Increases Metabolic Rate in MonkeysIt has become relatively silent around resveratrol in the past months. Many of its purported health benefits turned out to be less pronounced than early studies suggested and the availability of cheap high-quality supplements is still low. A new study published in BMC Physiology 2010, 10:11 (Dal-Pan. 09 July 2010) did however find a significant effect of resveratrol supplementation at 200 mg/kg/Adel Moussahttp://www.blogger.com/profile/11282066708304898697noreply@blogger.com