SuppVersity - Nutrition and Exercise Science for Everyone

Are you young and healthy? Then, high-dose NSAIDs may ruin your quad-gainz. If you browse the SuppVersity   Archive , you will find that NSAIDs, i.e. Non-Steroid(=not based on cortisone)-Anti-inflammatory-Drugs like aspirin, celecoxib, diclofenac, ibuprofen, or indomethacin, are not as bad as the bros in the locker-room may have told you. In fact, a relatively recent study by Mackey et al. (2016) observed  beneficial effects on muscle repair in young men . And an even more positive image of NSAIDs emerges if you read Trappe et al.'s 2016 study in which they observed significant increases in muscle gains in older trainees. Read about exercise- and nutrition-related studies in the SuppVersity Short News Alcohol, Microbes & International Chest Day Will Cooking Ruin the N3s in Your Fish? Learn What's Really Driving Your Gains HbA1c, Bone Health, BFR & More | Jan'17 TeaCrine®, ALA, Tribulus, Cordy-ceps, Sesamin... The Latest Fiber & ...

No, I still do not recommend the chronic (ab-)use of NSAIDs, bro. No, this is not the first study about the effects of NSAIDs on muscle gains I discuss here at  www.suppversity.com , but it is certainly one of the more interesting ones. The study which is about to be published in the FASEB Journal was designed to investigate the role of nonsteroidal anti-inflammatory drugs (NSAIDs) in human skeletal muscle regeneration. As you may remember, previous studies have yielded conflicting evidence with respect to the ability of NSAID to accelerate muscle healing and thus accelerater and ultimately shorten the adaptational process. Hormesis  is why soothing the inflammation is not always good for athletism Is Vitamin E Good for the Sedentary Slob, Only? Even Ice-Baths Impair the Adapt. Process Vit C+E Impair Muscle Gains in Older Men C+E Useless or Detrimental for Healthy People Vitamin C and Glucose Management? Antiox. & Health Benefits Don't Co...

Are NSAIDs over-the-counter anabolics from the pharmacy next door? Even though this is not the first SuppVersity  article about the effects of NSAIDs or COX-inhibitors like Aspirin, Tylenol, Pain-Eze and co., I would like to highlight one again  that the existing evidence suggests differential effects in young(er) vs. old(er) individuals, with the former seeing no or detrimental and the latter no or beneficial effects when using NSAIDs during resistance training regimen. It is thus neither guaranteed, nor likely that a young man or woman would see the same 28% extra-increase in type I fiber and 11% extra-increase in type II fiber diameter, Trappe et al. describe in their soon-to-be-published paper in the journal of the Gerontological Society of America  (Trappe. 2016). The link to hormesis research is far from being straight-forward Is Vitamin E Good for the Sedentary Slob, Only? Even Ice-Baths Impair the Adapt. Process Vit C+E Impair Muscle Gain...

Whether the text on this photo is actually true or not will be discussed in part II of this series, for now we are going to restrict ourselves to an analysis of the underlying reasons of DOMS and means to prevent that the pain becomes unbearable. An article by Alex Leaf (CPT) If you train regularly I’m sure you’re well aware of it, especially the morning following a heavy training session. Delayed onset muscle soreness (DOMS) is the sensation experienced upon waking the next morning and lasting upwards of 72 hours after a heavy exercise session. It is most commonly brought about through unaccustomed eccentric muscle action causing a disruption of connective and/or contractile tissue (Cheung. 2003). It is not a singular mechanism but rather a result of several mechanisms beginning with microtrauma followed by an inflammatory response (Lewis. 2012). Does DOMS influence exercise performance? Although DOMS may make you rethink taking the stairs the next day, its effect on exer...

Ever wondered how the "Modern-Day Samurai" of the Drummers of Japan keep in shape? Today's installment of True or False holds the answer to this and other questions ;-) True or false? That's the title of this no longer new series at the Suppversity and it is the question I want to answer after you read the following three statements: (1) "You can use glutamine instead of carbs to replete your glycogen stores", (2) "The only ones who benefit from the use of enterically coated and purportedly systemically acting enzymes are the the manufacturers of respective supplements" and (3) "Drumming burns about as much energy as fast jogging"... hmm, I see you're scratching your head!? Well, the unwritten rules of the game require that you make your prediction before you read the following paragraphs. So, true or false ? You can use glutamine instead of carbs to replete your glycogen stores True. There is yet one big caveat. The glu...

Myotubes under the microscope - vehicle (top, normal size), clenbuterol (+100% protein content, middle), clenbuterol + PGC1a4 inhibition (+50% protein content, bottom) Actually I would hope that you have by now already listened to yesterday's installment of the SuppVersity Science Round-Up . If you did, you are one of a group of highly privileged trainees who already knows why not all PGC1-alpha is created equal and how the alpha-4 isoform does appear to be the missing link between myostatin, on the one hand, and IGF-1 on the other. If you have already listened to the show, you may also have noticed that I was pretty excited about the publication of the Ruas paper (Ruas. 2012). Firstly this study has almost everything you could expect from cutting edge science: A in-vitro tudy to elucidate the basic mechanisms, an in-vivo rodent study involving both wild-type and genetically modified mice and - much to my own surprise - an in-vivo exercise part. And secondly, the results provi...