Caffeine-Resistance? Genetic & Environmental Factors Determine If You Feel or Don't Feel the "Boost" | Plus: 11 Non-Genetic Factors That In- & Decrease Caffeine's Effect

If you know the tricks you can increase and decrease your caffeine tolerance by varying environmental factors. Ramp up the amount of exercise, broccoli and smoked meats ➲ maximize the clearance and minimize the effects of caffeine. Actually I had hoped no-one would see the comment I made in the discussion revolving around a recent article about caffeine, but since a promise is a promise and I was stupid enough to promise that I would write an article on the genetic and environmental underpinnings of caffeine-over- and -under-metabolizers, I am sitting right here, digging up study after study, to find ... well, nothing conclusive. According to analysis Welfare et al. conducted and published in June 1999, there is actually no significant polymorphism in CYP1A2 in Caucasians which could explain the interindividual variation in caffeine activity, we all know exists (Welfare. 1999) - meanwhile, scientists have identified a handful of polymorphism - albeit with partly unknown acu...