Thursday, December 16, 2010

Melatonin for Patients With Metabolic Syndrome!?

When was the last time your mother asked you, whether you would get enough sleep? Can't remember? Well, a recent study by scientists (Kozirog. 2010) from the Department of Internal Diseases and Clinical Pharmacology at the Medical University of Lodz suggests you better listen to your mothers words and get a decent amount of sleep, just to make sure you reap the benefits of melatonin.

In the study 30 patients with metabolic syndrome (MS) were treated with 5mg/day of melatonin 2hr before bedtime for 2 month. The results were quite remarkable:
Melatonin administered for 2 months significantly improved antioxidative defense (increase in CAT activity, decrease in TBARS level) and lipid profile (decrease in LDL-C), and lowered blood pressure.
It is not news that lack of sleep contributes to metabolic disorders. What is interesting, however, is that direct supplementation with melatonin, which is secreted at dawn and in the course of the night reverses existing symptoms of the metabolic syndrome. In view of the complex endocrine interactions and the various hormonal responses which depend on sufficient and regular sleep, my suggestion is however not (only) to supplement tons of melatonin, but just to get a good nights sleep everyday, or, in other words, to practice "sleep hygiene", instead.