|Image 1: If you are concerned|
about the hormonal side(?)-effects
of persistent organic pollutants,
better make sure you buy pharma-
ceutical grade cod liver oil.
Still ahead of print is a study by Montano and some European colleagues (Montano. 2011). In their paper which will be published in the Journal of Food and Chemical Toxicology, the authors describe the effects of crude cod liver oil, pharmaceutical grade cod liver oil and the industrial waste that is produced in the manufacturing process of the former on human adrenocortical adenome cells. The latter are considered a valid tool to model the general effects of exogenous toxins on steroidogenic key pathways in humans. They will yet not provide quantitative dose response relationships between oral intake of "contaminated" fish oils. It would thus warrant further investigations how much of the "Crude Atlantic Cod Liver Oil" that was used in the study you would have to consume to achieve the (un-)desired(?) hormonal "boost" both the crude cod liver oil and the industrial residue induced even at the lowest (dilution factor 1/10000), the pharmaceutical grade oil only at the highest concentrations (dilution factor: 2.5/1000):
‘‘Cod’’[crude cod liver oil] mixture signiﬁcantly increased cortisol and P4 [progesterone] production at all concentrations tested. It also increased T [testosterone] production at 1E-3-dilution and E2 [estradiol] at the two highest concentrations. ‘‘Pharm’’ [pharmaceutical grade cod liver oil] mixture in contrast, was unable to signiﬁcantly trigger changes in hormone production, with the exception of increased E2 production by the highest concentration tested (2.5E-3-dilu-tion). However, the production of E2 triggered by the highest ‘‘Pharm’’ concentration was half from that produced by the exposure to ‘‘Cod’’ and ‘‘Ind Res’’ at the same dilution. ‘‘Ind Res’’ mixture signiﬁcantly induced the production of E2, P and Cort at 1E-3-dilution.Assuming that you do not consume the industrial waste (God knows what is in all those cheap fish oil products out there, though), the data in figure 1 shows that you would still ramp up your hormone production significantly (i.e. statistically significantly), as long as you bath your steroidogenic cells in high enough concentrations of polluted crude cod liver oil.
|Figure 1: Induction in hormone expression in human adrenocortical adenoma cells after incubation with crude cod liver oil (Cod) or pharmaceutical grade cod liver oil (Pharma) at doses of 1/10000 (E-4) and 1/1000 (E-3) relative to control (DMSO)|
(data adapted from Montano. 2011)