The two studies, on which my argumentation will be based were published in the diabetes journal Diabetologia (Zhang. 2011) and the journal of the Endocrine Society, Endocrinology (Pearen. 2011). Zhang and his colleagues from Singapore have studied the effects of my all-time favorite high-fat diet (HFD; 60% of the calories from fat, but by no means "low carb") on myostatin-null mice, mice fed with the type IIB receptor, sActRIIB, which binds and deactivates myostatin, and wild type mice - and I must say, their findings are quite exciting.
|Figure 1: Relative weight gain (compared to baseline, left) and haematoxylin and eosin stained adipocytes from WAT (right) of wild-type and Mstn − /− mice after 12 weeks of chow diet and HFD treatment (adapted from Zhang. 2011).|
|Figure 2: Relative increase in fatty ocid oxidation (compared to baseline, left) and decrease in non-esterified fatty acids of wild-type and Mstn − /− mice after 12 weeks of chow diet and HFD treatment (adapted from Zhang. 2011).|
Clenbuterol <> NOR-1 <> Myostatin
|Image 2: Alberto Contador knows about the "advantages" of Chinese fatstock (BBC. 2011)|
More than a word of caution!
Now, this would not the SuppVersity, if I did not conclude this post with a word of caution: Neither the (ab-)use of clenbuterol or ephedrine (which is a weaker beta-2 agonist, Yamahara. 1985) nor the myostatin-"binder" sActRIIB, which, by the way, rendered the wild-type mice similar resistant to diet-induced obesity as their genetically engineered myostatin-negative peers, constitute safe ways to get the muscular and fat-free physique of your dreams. Remember that before you throw away your grass-fed beef and begin importing Chinese fatstock ;-)