|Hops: More than an ingredient of the majority of OTC sleeping pills (photo LuckyStarr)|
Eat like a pig, look like a goddess with hops!
Actually the subheading is pretty unfair, after all pigs don't eat much different from us, they are opportunistic omnivores... but this is no biology lesson, so let's get back to the topic at hand. There was a time, when I thought that 99% of us would eat crap all day, if it would not make us fat - well, unless I realized that I would not and that there are many others out there who don't even like crap (=convenience food) who would refuse to eat pizza, chips, fries, pancakes, ... all day long. That being said, imagine you could do just that or, if you were a rodent in a lab cage, gorge yourself on a high fat diet with 30% maize starch, 14% casein, 10% sugar, 5% cellulose, 4% soyabean oil, 32.5% lard and some minerals and vitamins (546 kcal/100 g diet - calorically and macrowise this looks much like chocolate and candy bars to me ;-) and end up not just exactly as lean, but even a little leaner than your peers on a "healthy" after two years of gluttony? Sounds crazy? Yeah, but it worked!
In the latest study from the Ehime University Graduate School of Medicine in Japan (Sumiyoshi. 2013), the scientists demonstrated that 20 weeks on the previously described high fat diet (if you use the rule of thumb that a mouse year equals 40 human years this would be the aforementioned 2 years).
|Figure 1:Body weight trajectory and micrographs of the adipose tissue (Sumiyoshi. 2013)|
|Figure 2: Organ weights (rel. to group on standard chow) and blood glucose clearance in OGGT (Sumiyoshi. 2013)|
|Do you remember Rhein the natural PPAR-gamma antagonist in Rhubarb? No? Then I suggested you go back in the archives and (re-)read the respective article. You will be surprised how similar the results were... a total amelioration of the HFD induced weight gain, normal body fat levels and no insulin resistance - sounds familiar, no?|
According to the researchers, "[e]xperiments are now in progress to isolate the active substance(s) of hop extract". However, we all know that once this substance is found, the "logical" (actually this is business, not real logic) next step is to add a twist that turns it into a patentable not naturally occurring molecule and make counterproductive and (business logic) no longer really profitable PPAR-gamma agonists with another drug.
- Sumiyoshi M, Kimura Y. Hop (Humulus lupulus L.) extract inhibits obesity in mice fed a high-fat diet over the long term. Br J Nutr. 2013 Jan;109(1):162-72.