|Breakfast of a supplement junkie.|
Despite all recent regulatory efforts the FDA is having a hard time to keep up with the tricks of the "supplement" industry who releases one structurally slightly modified, but effective AAS derivative after the other.
More specifically, most designer steroids are orally formulated with varying degrees of bioavailability. Some compounds are 17-alpha alkyl ated to improve the oral bioavailability of injectable pharmaceutical androgens, but this modification increases the toxicity of the androgen (Kazlauskas. 2010).
By slightly modifying the original chemical structure of potent androgens "supplement" companies have been successfully selling potent androgens without technically selling controlled substances by using pro-drugs that are unclassified compounds in the bottle, but in vivo are metabolized to Schedule III Controlled AAS for decades.
"The designer steroid methasteron (Superol) is an example of the hepatotoxicity associated with the consumption of 17-alpha alkylated steroids. This oral AAS, also known as methyldrostanolone, was sold over-the counter until 2012 and is a methylated (17-alpha alkylated) version of the injectable steroid drostanolone (Masteron).
Figure 1: Cyclic process of designer steroid discovery, synthesis, distribution, and regulation (Rahnema. 2015).
Consumption of methasteron as a dietary supplement for bodybuilding has been reported to cause severe hepatotoxicity, cholestasis, and acute renal failure" (Rahnema. 2015).
No, I am not trying to vilify these compounds. I don't want to point with a finger at people who are using them, either. I just want you to know that the evidence that the dreaded "Superdrol" is not the only agent that can harm your health is there - even though it may be scarce. As a responsible grown up person, it's obviously up to you whether you want to use a designer steroid or not. Just don't make the mistake and believe that popping pills alone could make up for your messed up diet and training regimen which hasn't yielded any results over the past two years.Compounds like boldione or prostanozolol which have been banned in 2010 and 2012, respectively, are only the tip of the iceberg (Baume. 2006; Geyer. 2008; Kazlauskas. 2010). More recently other agents have been dominating the market. Agents like ...
- dimethazine - 2a,17a-dimethyl-5a-androstan-17b-ol-3,3 0-azine or 2a,17a-dimethyl-5a-androstan-17b-ol-3-one-azine aka DMZ,
- methylepitiostanol - 2a,3a-epithio-17a-methyl-5a-androstan-17b-ol aka Epistane,
- methoxygonadiene - 13b-ethyl-3-methoxy-gona-2,5(10)-dien-17-one aka Methadrol,
- methylclostebol - 4-chloro-17a-methyl-androst-4-en-17b-ol-3-one aka P-Mag,
- methylstenbolone - 2,17a-dimethyl-17b-hydroxy-5a-androst-1-en-3-one aka M-STEN,
- mentabolan - 7a-methyl-estra-4-en-3,17-dione ake MENT, and
- trestione - 7a-methyl-19-norandrostenedione aka TREST
|Table 1: Currently unscheduled designer steroid | a designer steroids from the WADA Prohibited List (Rahnema. 2015)|
|Table 2: Parent compounds, testosterone, nandrolone and associated compounds from Baume et al. (2006).|
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