|The yellow seeds of the lupine plant, known as lupin beans, were once a common food of the Mediterranean basin and Latin America - almost "paleo" ;-)|
In the first study by Harisa et al. a single 43-year-old man with obesity, hypertension, hypercholesterolemia, hyperuricemia and mild liver dysfunctions was put on a lupid (Lupineus luteus) containing low carbohydrate diet + improved lifestyle regimen for 6 years.
The body weight, body mass index (BMI), blood pressure, total cholesterol (TC), low density lipoprotein-cholesterol (LDL-C), triacylglycerol (TAG), uric acid (UA) and alanine transaminase (ALT) were markedly decreased by 26.85%, 26.95%, 13 %, 53.84%, 57.84%, 36.14 %, 47.58 % and 61.62 % respectively, compared to those at baselines. The same goes for the body weight that was reduced by 16% within the first 3 months and 27% after the full 6 months study period.
|Figure 2: Comparison of the effects of lupines and oats as an add-on to calorie reduced diets on obese rodents (Chabane. 2013)|
What has already been studied in humans is the effect of ephedrine...
and I am not talking about the hushed up studies that show that it is a relatively safe and highly effective anti-obesity drug. Rather than that, I am talking about the latest study of its chronic administration on the activity of brown adipose tissue in a randomised controlled human trial (Carey. 2015).
Previous studies have shown that brown adipose tissue (BAT) activation increases energy expenditure and may have therapeutic potential to combat obesity. The primary activating and adaptive signal for BAT is via β-adrenergic signalling. Carey et al. have previously demonstrated that human BAT is acutely responsive to oral administration of the sympathomimetic, ephedrine.
|Figure 3: Effects of ephedrine treatment on body weight & composition of normal-weight healthy men (Carey. 2015).|
- Carey, Andrew L., et al. "Chronic ephedrine administration decreases brown adipose tissue activity in a randomised controlled human trial: implications for obesity." Diabetologia (2015): 1-10.
- Chabane, Fatima Z., et al. "Effects of Two Hypocaloric Diets Supplemented With White Lupine or Oats on Lipid Peroxidation, Reverse Cholesterol Transport and Paraoxonase Activity in Obese Rat." Journal of Food Research 2.5 (2013): p1.
- Harisa, Gamaleldin I., and Fars K. Alanazi. "The beneficial roles of Lupineus luteus and lifestyle changes in management of metabolic syndrome: A case study." Saudi Pharmaceutical Journal (2015).