|MyoPS - muscle damage = gainz - It's as easy as that, but this simple equation gets complicated by decreases in both...|
In the introduction to their latest paper, Felipe Damas et al. (2016) highlight our lack of understanding of the different mechanisms that eventually determine t he hypertrophy response to resistance training.
To investigate how muscle hypertrophy is modulated through RT, Damas et al. "measured day-to-day integrated myofibrillar protein synthesis (MyoPS) using deuterium-oxide ingestion and assessed muscle damage at the beginning (T1), at 3wk (T2), and 10wk of RT (T3)" in a study that involved ten young men (27(1) y) who had muscle biopsies (vastus lateralis) taken to measure integrated MyoPS and muscle damage (Z-band streaming and indirect parameters) before and 24h and 48h post-resistance exercise (RE) at T1, T2 and T3.
|Figure 1: Experimental design. RE: resistance exercise; D2O: deuterated water; MVC: maximal voluntary isometric torque; SOR: muscle soreness; T1: 1st week of resistance training (RT); T2: 3rd week of RT; T3: last week of RT (Damas. 2016).|
|Figure 2: Fibre cross-sectional area (CSA) at the first week (T1), third week (T2) and tenth week (T3) of resistance training. † Significantly different (P < 0.05) from T1 and T2. Values are means (SEM | Damas. 2016)|
- Damas, Felipe, et al. "Resistance training‐induced changes in integrated myofibrillar protein synthesis are related to hypertrophy only after attenuation of muscle damage." The Journal of physiology (2016).
- Mitchell, Cameron J., et al. "Acute post-exercise myofibrillar protein synthesis is not correlated with resistance training-induced muscle hypertrophy in young men." PLoS One 9.2 (2014): e89431.