SuppVersity - Nutrition and Exercise Science for Everyone

Methylation is the most common form of in vivo miRNA modification ( the Scientist ) Micro-RNAs aka miRNAs are small non-coding RNAs that regulate gene expression at the post-transcriptional level... What? I suppose you have heard of epigenetics? Well, miRNA molecules also play a role in epigenetics by triggering "post-transcriptional" changes, i.e. in between the transcription and the translation of a gene. It is thus not surprising that there is growing evidence that they are involved in a plethora of biological processes - biological processes in the course of which they occur naturally, processes like exercise, for example. If you want to build muscle forget T-booster and optimize your  protein intake   Protein Timing DOES Matter! 5x More Than the FDA Allows! Protein requ. of athletes High EAA protein for fat loss Fast vs. slow protein Whey vs. Pea Protein More recently, scientists have found out more and more about the way miRNAs play a deci...

In a recent study, European scientists ( Membrez. 2010 ) found that sebacic acid, a natural ingredient of castor oil improves blood sugar control in a mouse model of diabetes. The scientists fed their mice a diet containing 1.5% or 15% of sebatic acid (SA) over a period of 6 weeks and found: After 42 days of supplementation, fasting glycaemia and HbA1c were ∼70 and 25% lower in the SA 15% group compared with the other groups showing a beneficial effect of SA on hyperglycaemia. During OGTT, plasma glucose area under the curve was reduced after SA 15% compared with the other groups. This effect was associated with a tendency for an improved insulin response. In the liver, Pck1 and FBP mRNA were statistically decreased in the SA 15% compared with Ctrl suggesting a reduced hepatic glucose output induced by SA. While these are certainly encouraging results, it remains questionable whether or not it would be feasible for humans to achieve sufficiently high sebatic acid intake to ...