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Beta-Alanine, Widely Used, but Rarely Tested for Safety!? Individual Studies Find Serum / Muscle Taurine is Reduced by >20%, However the Totality of Evidence Suggests...

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Reductions in muscle and especially serum taurine have indeed also been observed in humans, but the fact that they do not occur in lower dose studies and cannot be observed consistently in studies using higher dosages (6g) suggests that they shouldn't be a problem for the average BA user. Regular SuppVersity  readers will be familiar with the way(s) in which taurine (#TAU) and beta-alanine seem to both complement and antagonize each other. Beta-alanine, in particular, has been found to deplete muscular (and other tissue) taurine stores - a problem, generations of scientists have used to study the ill health effects of taurine-deficiency. While studies have never reported clinical taurine depletion in response to beta-alanine supplements, we have to consider the possibility that ... If it works (no runs + high intensity+volume exercise) bicarbonate is the king of H+buffers: Caffeine + Bicarb Make Champions Bicarb + Asp = Muscle Magic!? NaCHO3 & Leg Days're...

Dubious Effects of Creatine on Markers of CNS Adaptation and Heart Health in "Bodybuilders" - Reason to Be Afraid?

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Bodybuilding and creatine ain't mentioned in one breath without a reason - Crea simply works! Dozens of studies have shown that... not one, however, tested the effects on the CNS. Based on the extreme excitement I observed in response my recent Facebook News  item on creatine's ability to reduce the sleep requirements in a rodent trial [ (re-)read it ], I assume that you'd like to learn about more or less every study on everyone's favorite ergogenic - correct? Not every study? Oh, yes, obviously, study #103 showing that creatine yields strength and size increases on your average hypertrophy workout would indeed no longer be news-worthy. Much in contrast, however, to a study that claims that creatine may blunt the beneficial effects of resistance training on heart health ? Ok, I see that's getting you excited. So let's take a closer look at how the authors come up with claim... You can learn more about creatine at the SuppVersity Creatine Doubles ...

Creatine Safe! For Diabetics, as Well.

Ever since creatine has been introduced to the supplement market there is a certain part of the medical establishment who condemns every body builder's favorite supplement as kidney killer no1 . While there have been numerous studies that showed that healthy people are not at risk of kidney problems or even kidney failure from creatine consumption the study by Gualano et al. (Gualano. 2010) is the first to show that even type 2 diabetics can safely consume creatine: The creatine group presented higher muscle phosphorylcreatine content when compared to placebo group (CR Pre 44 ± 10, Post 70 ± 18 mmol/kg/wt; PL Pre 52 ± 13, Post 46 ± 13 mmol/kg/wt; p = 0.03; estimated difference between means 23.6; 95% confidence interval 1.42-45.8). No significant differences were observed for (51)Cr-EDTA clearance (CR Pre 90.4 ± 16.9, Post 96.1 ± 15.0 mL/min/1.73 m(2); PL Pre 97.9 ± 21.6, Post ...
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