In a double-blind, randomized, parallel and active-controlled clinical study (Susalit. 2010) an international team of scientists found that after a run-in period of 4 weeks continued subsequently by an 8-week treatment period supplementation with Olive (Olea europaea L.) leaf extract (EFLA®943) at 500 mg twice daily was equally effective in reducing blood pressure as the ACE inhibitor Captopril, which was given at the dosage regimen of 12.5 mg twice daily for the first two weeks and (if necessary) at 25 mg twice daily for the rest of the treatment period:
After 8 weeks of treatment, both groups experienced a significant reduction of systolic blood pressure (SBP) as well as diastolic blood pressure (DBP) from baseline; while such reductions were not significantly different between groups. Means of SBP reduction from baseline to the end of study were −11.5 ± 8.5 and −13.7 ± 7.6 mm Hg in Olive and Captopril groups, respectively; and those of DBP were −4.8 ± 5.5 and −6.4 ± 5.2 mm Hg, respectively.What is even more intriguing is the concomitant reduction in triglyceride level, which was observed exclusively in the Olive, but not in Captopril group.
|Figure1: Plasma Triglyceride levels throughout the study in the subgroup with baseline triglyceride level of > 200 mg/dl (Susalit. 2010).|