Monday, January 31, 2011

Resveratrol Increases Lipolysis and Reduces Lipogenesis in Mature Adipocytes

If you are (as I hope) an avid reader and daily visitor of the SuppVersity, you probably remember Friday's news on the "Side Effects of Polyphenol Supplementation". I just hope you did not throw away all your supplements immediately, because eventually the question of side effects is always relative. If, for example, you are a sumo competitor and in dire need of gaining mass, no matter what. It would be an unwelcome side-effect of resveratrol supplementation not to gain or even to lose body fat...

A report (Baile. 2011), recently published in the Annals of the New York Academy of Sciences does now confirm, what supplement companies have been promising all along: the right dose of supplemental resveratrol will limit fat gain and improve lipolysis in a mouse model:
Treatment of mice with resveratrol alone was shown to improve resistance to weight gain caused by a high-fat diet. Moreover, dietary supplementation of aged ovariectomized rats with a combination of resveratrol and vitamin D, quercetin, and genistein not only decreased weight gain but also inhibited bone loss.
The human equivalent dose to that used in the cited study would be about 35mg/kg (= 2.800mg for a 80kg human being), which, unfortunately, is much more than your average resveratrol product contains. So, what does this tell you? Either you spend a fortune for minor improvements in your resistance to an unhealthy diet OR you just consume a healthy diet in the first place - I bet you will end up leaner and healthier using the second option.