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DHEA Inhibits Fat Gain More Effectively Than Testosterone. Both Work by Reducing PPAR-γ and Thusly Lipid Storage

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Image 1: This is the "Fountain of Youth" in Karlsruhe, Germany. I have never been there, but I guess I should take the next train and check whether water contains 0.4% or 0.8% DHEA ;-) Outside of the medical practices of some anti-aging docs nobody appears to care about the "good old" dehydroepiandrosterone (DHEA), these days. As a diligent student of the SuppVersity, you are yet well aware of the reviving effects DHEA has on the liver (cf. August, 26, 2011 ), pancreas & insulin sensitivity (cf. May, 15, 2011 ) and adipocyte metabolism (cf. April, 8, 2011 ) in "older" people or everyone with suboptimal DHEA levels. You will also be aware that the adrenal steroid hormone which can be converted to testosterone (and thusly DHT or estrogen) at the target tissue exerted pretty astonishing effects on body composition in a handful of initial (very) high-dose trials. Follow up studies in the late 1990s were yet mostly unable to reproduce these encouraging...
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Fat and Impotent Due to Tributyltin? Not Adipogenetic or Estrogenic, But Adipogenic and Estrogenic. Organotin TBT Dose-Dependently Increases Fat Deposition and Estrogen Receptor Activity.

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Image 1: Chemical structure of tributyltin; the organotin is a common ingredient in pesticides, anti-fungals and marine paints Although large parts of the industry won't concede to it, many of the invisible pollutants of our "post-industrial" age are just as, or even more dangerous than the nasty air and water pollutants of the Industrial Revolution. One of these invisible killers is the organotin, tributyltin (TBT) . It has been long established that TBT exposure during fetal life promotes adipogenesis and predispositions to a multitude of health problems in later life ( Grün and Blumberg, 2006 ) . Other than in other environmental toxins, such as Bisphenol A, it has been established only very recently that TBT may act as an estrogen receptor agonist, as well - in fact, in previous (low-dose) studies ( Lissimachou. 2006 ; Mortensen. 2007 ; Zhang. 2009 ) the exact opposite appeared to be the case. ...
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Resveratrol Increases Lipolysis and Reduces Lipogenesis in Mature Adipocytes

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If you are (as I hope) an avid reader and daily visitor of the SuppVersity, you probably remember Friday's news on the " Side Effects of Polyphenol Supplementation ". I just hope you did not throw away all your supplements immediately, because eventually the question of side effects is always relative. If, for example, you are a sumo competitor and in dire need of gaining mass, no matter what. It would be an unwelcome side-effect of resveratrol supplementation not to gain or even to lose body fat... A report ( Baile. 2011 ), recently published in the Annals of the New York Academy of Sciences does now confirm, what supplement companies have been promising all along: the right dose of supplemental resveratrol will limit fat gain and improve lipolysis in a mouse model: Treatment of mice with resveratrol alone was shown to improve resistance to weight gain caused by a high-fat diet. Moreover, dietary supplementation of aged ovariectomized rats with a combination o...
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