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Ursolic Acid and The Narrow Line Between Anabolism and Myotoxicity: +25% Increased Protein Accretion in In-Vitro Study, But Cell Death With 2x "Effective" Dose

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Image 1: "An apple a day keeps the doctor away!" And though the ursolic acid in its peel may be part of the underlying mechanism, this does not make it a "natural anabolic", but rather another item on the list of "healthy stuff from real food" The number of purported natural anabolics increases year by year. Against the background that most of these products are nothing but supplemental nonstarters in shiny bottles and boxes with "non-FDA approved" promises of "unparalleled muscle growth" on them, the recent release of a broad range of ursolic acid supplements must already be considered a "highlight". With a peer-reviewed rodent studies backing its anti-catabolic, pro-anabolic properties ( Kunkel. 2011 ), it appears as if ursolic acid could be more than another potent placebo. And if we put things into perspective, in the end its potential beneficial effects on skeletal muscle hypertrophy are rather negligible compared to...
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Intermittent Thoughts on Building Muscle: The Skeletal Muscle Hypertrophy 101 - Part 2: Getting Big Means Growing Beyond Temporary Physiological Limits.

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Image 1: This is another type of "dysfunctional muscle"; distinct from the one we are talking about, here Although I assume that you all have read the last installment of the Intermittent Thoughts, I took FatFree's comment that he (or she?) was missing the " too comlicated check box" from the old design to the heart (I do so with every comment, btw, so keep them coming) and kick off today's installment of "The Thoughts" with a brief and even more "dumbed down" summary of what we have learned about the (possibly) ascertained and, even if human skeletal muscle hyperplasia existed, dominant factors in the trinity of skeletal muscle growth: Protein synthestic increases in myonuclear domain sizes and the satellite cell driven incorporation of new myonuclei. Getting big goes beyond ballooning up You probably will remember the balloon-metaphor, I introduced in the red infobox toward the end of the last installment . Let's briefly...
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Intermittent Thoughts on Building Muscle: The Skeletal Muscle Hypertrophy 101 - Part 1: What is Hypertrophy?

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Image 1: Governator, Arnold Schwarzenegger, as a teen and in his early twenties. What - puberty aside - were the underlying mechanisms of the obvious increase in sleeve-size? I mean on a strictly myocellular level, of course ;-) Those of you, who have been following the Intermittent Thoughts series over the last weeks will probably already have realized that I finally dropped the "Intermittent Fasting" from the title ... this is something I have been thinking about for quite some time now. After all, the series has evolved way beyond its initial focus on a specific dietary protocol and has become more of an educational " how do you find your way to success "-series. With the format, intermittent thoughts , being still the same, the upcoming posts in this series, which will certainly touch on the topic of intermittent fasting, again, will be titled "Intermittent Thoughts on..." whatever the topic of the week may be ... and for this week's insta...
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