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TReaTing Diabesity With Testosterone!? If You Keep DHT in Check + Stay Away From Aromatase Inhibitors, It May Work

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It probably won't turn an overweight pre-diabetic into a fitness model, but a getting a TRT script has the potential of changing a man's physical and psychological health for the better. Despite the fact that more and more men recognize the benefits of supervised testosterone replacement therapy (TRT) and the bodybuilding and fitness community cherishes 'their BIG T' as the be-all-and-end-all, many medical practitioners look at the administration of exogenous androgens as a potential health hazard. I would even bet that it won't be difficult to find one or two MDs who would say that Patricia S. Juang et al.'s idea to administer testosterone to obese men with normal, but low baseline testosterone levels to improve their body composition and insulin sensitivity borders physical injury - and that irrespective of adjuvant 5α-reductase (dutasteride) or aromatase (anastrazole) inhibitor administration. TRT w/ or w/out aromatase or 5α-reductase inhibitor? It ...
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Less Than 15mg of DHEA Exert Identical Beneficial Effects on Insulin Sensitivity as 1h of Cardio 5x Per Week. Both Effects Mediated Via Increases in Intra-Muscular DHT

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Image 1: It has long been established that diabetics have particularly low DHEA levels ( Loviselli. 1994 ), but what's the chicken and what's the egg here? It is quite funny, sometimes you don't hear about certain supplements, (pro-)hormones, exercise-modalities etc. in years and then, all of a sudden, there are two studies on the respective topic in one week; and moreover, two pretty interesting ones! Last Friday, exactly 7 days ago, you've read here at the SuppVersity about the muscle-protective effects of low-dose dehydroepiandrosterone (DHEA) supplementation during a 5-day intense multiple-type exercise protocol (cf. " DHEA Blunts Muscle Damage During 5 Days of Combined Endurance, Strength and HIIT Training in Young Men "). Today, I have another interesting set of data for you - data which could not just shed some light onto the underlying mechanisms of the said protective effects against skeletal muscle damage, but also on DHEA's beneficial effe...
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Chest Fat, Bitch Tits, Chesticles, Gynecomastia, Lipomastia and Co.: Infinite Ways to Name it, Only 5 to Get Rid of It

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Image 1: Is it what he eats, is it what he drinks or is it just  andropause? Whatever it may be, Jack does not have the "classic gyno". In the last installment of this two-part series on gynecomastia, lipomastia and co. we have seen that the number of appellations this common, mostly benign enlargement of the male breast has been given, is easily outnumbered by the potential, mostly pharmacological, but also supplemental and/or dietary factors which have been implicated in its development. In a recent paper, Krysiak and Okopien estimate the incidence of mild proliferation of the glandular breast tissue to 30%-50% of the male population ( Krysiak. 2012 ). Against that background, the universal ignorance towards the profound psychological effects, as well as the tacit acceptance that, breasts or no breasts, "men don't cry" are certainly uncalled-for. If it's benign you got to live with it! The idea, "if it's not cancerous", it won...
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Natural Hormone Optimization Made Simple & Cheap: Avoid These 10 Anti-Androgens to Boost Testosterone & DHT

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Image 1: I am not aware of the effect the process of making yourself up has on androgen levels, but the PCPs in many cosmetics could in fact lead to hormonal imbalances. One of the things you hear and read increasingly often, when it comes to topics such as detoxification , the use of anti-inflammatory supplements or simply increased intakes of omega-3 fatty acids to counter the "hazardous omega-6 overload in your diet" , is the analogy of somebody banging his head against a wall asking for a helmet, instead of simply stopping this stupid practice. Likewise, it does not really make sense to invest $50 into an already more or less worthless natural testosterone booster, when, at the same time, you are eating or even supplementing one of the items on the following list of proven anti-androgens: anti-androgenic drugs - cyproterone acetate, spirolonactone, flutamide, ketoconazole, finasterid e & co.: It stands to reason that your doctor will have had good reason to pre...
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Dustasteride Doesn't Hamper Mass & Strength Gains on TRT, but Compromises the Fat Loss Effects of Testosterone and Does Not Reduce Any of the Side Effects

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Image 1: I guess after the publication of his latest study, Mr. Bhasin will have a bad standing with the pharma reps from GlaxoSmithKline & Co ;-) What happens if you take a couple of healthy guys and put them on a cycle... ah, pardon, I mean, "put them on hormone replacement therapy"? Assuming that you have paid attention in the seminars of the Intermittent Thoughts Series on Building Muscle (cf. " Preliminary Conclusion + Summary "), particularly the part " Quantifiying the Big T ", it should not be difficult for you to answer: The guys will gain a few slabs of lean muscle mass! But what would happen if you added in some finasteride , or it's uber-potent cousin dustasteride ? Will you gain more or less? Will you be protected from acne and prostate growth? The "Big T" as in "Testosterone" or as in "Taboo"? As an MD you are not supposed to ask these questions... you are not even supposed to put your male patien...
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Intermittent Thoughts: Dihydrotestosterone (DHT) - Bigger, Stronger, Faster or just Balder, Fatter and Unhealthier?

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Image 1: The ancient Greek ideal of the male body has probably more to do with DHT than the freaky physiques of today's IFBB Pro bodybuilders. I guess after the revelations about the importance of estrogen in the process of skeletal muscle hypertrophy in the last installment of the Intermittent Thoughts you will probably be eager to hear what its male counterpart dihydrotestosterone (DHT), is able to do... I mean, with DHT being the male hormone par excellence it is only reasonable to assume that its effects on skeletal muscle mass and strength, two characteristic features of the male persuasion, must be significant, right? Before we are going to address this vitally important questions, let's briefly take a look at what the dihydrotestosterone actually is. DHT the hormone to which testosterone is just another prohormone Similar to estrogen, DHT (exact name 17β-hydroxy-5α-androstan-3-one ) is a testosterone metabolite. The process by which your body (male and fema...
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Problems with High or Low DHT? Use Rice or Safflower to Inhibit and Sorghum to Promote 5-Alpha Reductase!

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Image 1: High or too low DHT levels? Nature has the cure for both. Lower your DHT levels with rice bran or safflower flower extracts or raise it with a crude extract from Sorghum bicolor seeds. Hairloss for men, and even more so for women, is certainly one of the nastiest side effects of either naturally or artificially induced hormonal disturbances. And while the vilification of DHT as the #1 inducer of male pattern baldness and a potential cause of female hair loss may be overblown, it is a well-established fact that (over-)expression of DHT, or rather a high / over-activity of the 5a-reductase enzyme which converts testosterone to the ~10x more potent androgen dihydrotestosterone will, over time, lead to a shrinkage and gradual disappearance of affected hair follicles . In that, it is noteworthy that similar to the carcinogenic effects estrogen exerts on female (and male) breast tissue, it is mostly the local and not so much the systemic reduction of testosterone to DHT, or, in...
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