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IL-6 - True Muscle Builder or Just a Measure of Workout Intensity? Plus: If Testosterone Does Not Matter, Why Does the Androgen Receptor Density Make a Difference?

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No matter how close we look, the influence of previous, i.e. GH, IGF-1 and testosterone, as well as novel, i.e. IL-6 and AR expression, potentially growth promoting suspects remains elusive. SuppVersity readers know, there is more to " inflammation " than the average mass media article will make you believe. The same "bad cytokines" that will decrease your insulin sensitivity, make you sick and obese, when they leak from your "inflamed" beer belly, are actually the good guys, when they are released in response to a workout from the musculature. "Myo-", not "cytokines", that's how researchers refer to them (Pedersen. 2007); and their role in (exercise) metabolism and immunity is until now still not fully understood. The results the scientists from the McMaster University probably won't add much to our understanding of the systemic effects of IL-6 and other myokines. What certainly do, though, is to support the notion that ...
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Understanding Muscle Hypertrophy - Study Sheds More Light on Process of Satellite Cell Recruitement: SRF, IL-6, STAT3, COX2, IL4 + More Funky Acronyms With Important Roles in the Structural Component of Muscle Growth.

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No pain inflammation, no gain? In the long(er) run this could in fact be true. All of you who followed my advice to "like" the SuppVersity Facebook page and are thus keeping up with the numerous additional news I am posting there, should actually have seen the news item on the non-significance of the exercise-induced interleukin-6 (IL6) response for the exercise induced improvements in glucose metabolism ( read more ). The mere fact that the glucose metabolism of IL6(-) mice, which are mice who simply cannot express IL6, is still improved by "working out" does yet by no means preclude that the demonized cytokine does play a fundamental role in the exercise-induced systemic and local benefits. In fact, an even more recent rodent study would suggest that a certain degree of inflammation and the respective increase in IL6 immediately after a workout is even essential for persistent skeletal muscle hypertrophy. As you may remember from the Intermittent Though...
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Omega 3 Attenuates Exercise Induced Rise in Inflammatory Markers, BUT is This Necessarily a Good Thing?

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I want to take the results of a recent study ( Bakhtyar. 2011 ) published in the Clinical Journal of Sport Medicine as an opportunity to readdress the question of whether or not the Omega 3 induced suppression of inflammation must be considered a good or a bad thing, both in view of athletic performance, as well from a health and longevity perspective. Those of you, who listened to my interview on Carl Lenore's Super Human Radio show , will know that my understanding of "inflammation" is somewhat different from the mass market "explanation" of "a fire that causes damage". To be precise inflammation, or what scientists generally measure, is the release of signals (inflammatory markers) that tell immune cells to do their jobs. So, saying that inflammation is the root of all disease would be like saying that someone who calls the firefighters is to blame for the fire - but I am digressing from the topic at hand... After administering 1.5g/day of an om...
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