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Ask Dr. Andro: Are Vitamin Supplements Bad For Me (1/2)? The "wrong" Vitamin E Supplements Increase Cancer Risk.

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Figure 1: This is where you, my American friends (and most Europeans), should and would get your "E's" from - it's called "food" ( Eitenmiller. 2004 ) With the recent publication of two studies on increased all-cause mortality in older women ( Bjelacovic. 2011 ; Mursu. 2011 ) who took multivitamins (+2.4%), vitamin B6 (+4.1%), folic acid (+5.9%), iron (+3.4%), magnsium (+3.6%), zinc (+3.0%), and the "killer" copper (+18%) and increased risk of prostate cancer due to selenium and/or vitamin E supplements ( Klein. 2011 ) on a regular basis and the huge media attention these studies, " Certain Dietary Supplements Associated With Increased Risk of Death in Older Women, Study Suggests " " Vitamin E Supplement May Increase Prostate Cancer Risk, National U.S. Study Finds " have received, I got interested in taking a closer look at what I would usually have discarded as epidemiological guesswork and scare tactics , anyway. ...
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Vitamin(S!) E, The Whole Picture: Delta Tocopherol a Rising Star in Cancer Protection

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Those of you who have attentively followed my dissertation on fish oil (cf. SHR: ProfDrAndro talking on the Pros & Cons of Fish Oil ) may remember that - as an aside - I mentioned that not alpha-tocopherol , which is what supplement companies add to their fish oils, but delta-tocopherol would be the anti-oxidant of choice to protect the highly oxidizable oil from going rancid. Figure 1: Toco-8 , one of the few tocotrienol products on the market A very recent report ( Li. 2011 ) on findings of scientists from The State University of New Jersey is only one out of a whole line studies that imply that the real health value of "vitamin E" (we should better start writing "the vitamins E") does not lie in one, but in the combination of the tocopherols (alpha, gamma, delta) and the naturally ocuring tocotrienols , of which both the delta-tocopherol, as well as the group of tocotrienols have long been overlooked in the course of what one should probably call th...
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Epidemiological Study Shows Correlation Between Anti-Oxidant Intake and C-Reactive Protein & Homocystein

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After a sudden onset of discussions around the beneficial or even detrimental effects of vitamin supplements in general and antioxidants in particular in the mid to late 2000s, vitamins and, even more, other anti-oxidants have been put back on the map, lately. A recent epidemiological study from the University of Connecticut ( Floegel. 2011 ) provides further evidence for the hypothesis that, after all, consumption of adequate amounts of vitamins C and E , beta carotene , flavonoids and selenium would be beneficial to your overall health Intakes of vitamins C and E and carotene were inversely associated with the probability of having serum CRP concentrations >3 mg/l in multivariate logistic regression models. Flavonoid and Se intakes were not associated with the odds of elevated serum CRP concentrations. The mean plasma Hcy concentration was 8·61 (95 % CI 8·48, 8·74) μmol/l. Intakes of vitamins C, E, carotenes and Se were inversely associated with the odds of plasma H...
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Dietary Oxidized Frying Oil Impairs Pancreatic Insulin Release. Vitamin E Helps!

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It certainly is no coincidence that a recent study on the detrimental effects of oxidized frying oil (OFA) was published in the British Journal of Nutrition . Afterall, it suggests that the British are at risk of dying out, if they just listened to their appetite and kept over-consuming "Fish and Chips". After feeding rats with either soy (HF) or oxidized frying oil (HO) over a period of 8 weeks the researchers found: [...] mice in the HO group showed glucose intolerance and hypoinsulinaemia, and their islets showed impaired glucose-stimulated insulin secretion (P,0·05; HO group v. LF and HF groups). Significantly higher oxidative stress and a lower mitochondrial membrane potential were observed in the islets in the HO group compared with the LF and HF groups. Immunoblots showed that the reduction in insulin levels in HO islets was associated with activation of the c-Jun NH2-terminal kinase and a reduction in levels of pancreatic and duodenal homeobox Furthermore, they ...
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Endurance Athletes Benefit from Anti-Oxidant Supplementation (Vitamin E, Vitamin C & beta-carotene)

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Lately, the discussion about the benefits of anti-oxidants has taken a turn. Studies and reviews have questioned the use or necessity of supplemental anti-oxidants to athletes diets and some have even claimed that overt use of anti-inflammatory supplements would reduce training success. In a recent study Acquilo et al. (Acquilo. 2010) have supplemented 18 amateur trained male athletes randomly with placebo or a mix of antioxidants (vitamin E, 500 mg/d; vitamin C, 1 g/d; and b -carotene, 30 mg/d) in the course of their usual training and competition season. The scientists found that Exercise decreased antioxidant defenses in the placebo group but not in the antioxidant-supplemented group . No changes were found in the number of erythrocytes, hematocrit, or hemoglobin concentration, or in values of serum iron parameters, after taking the antioxidant cocktail for 3 months, in spite of the exercise completed. The placebo group showed a high oxidative stress index, and decrea...
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Do Your Sperm a Favor: Eat Salmon not Soy!

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In a recent investigation Brazilian scientists (Moraes. 2010) found that vitamin E from salmon, but not soy oil, has beneficial effects on sperm motality and resistance to cooling to 17° respectively 5°. The scientists supplemented twenty-four Dalboar 85 boars with three different amounts of antioxidants (150, 300 and 450 vitamin E mg/kg) from one of the sources and conducted a few standard tests at 24h, 48h, and 72h after the supplementation: Salmon oil increased the vigor in both temperatures evaluated after 24 and 48 hours. The occurence of total morphological abnormalities was higher in the semen of animals fed soybean oil and cooled at 17ºC while in the lowest cooling temperature (5ºC) there was no difference among animals under supplementation. [...] Salmon oil improves the sperm characteristics of the boar semen cooled at 17 and 5ºC from 24 to 48 hours. "No soy boy!". The good old BB-saying holds true no matter how hard animal rights activists are pushing to get me ...
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