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Less Than 15mg of DHEA Exert Identical Beneficial Effects on Insulin Sensitivity as 1h of Cardio 5x Per Week. Both Effects Mediated Via Increases in Intra-Muscular DHT

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Image 1: It has long been established that diabetics have particularly low DHEA levels ( Loviselli. 1994 ), but what's the chicken and what's the egg here? It is quite funny, sometimes you don't hear about certain supplements, (pro-)hormones, exercise-modalities etc. in years and then, all of a sudden, there are two studies on the respective topic in one week; and moreover, two pretty interesting ones! Last Friday, exactly 7 days ago, you've read here at the SuppVersity about the muscle-protective effects of low-dose dehydroepiandrosterone (DHEA) supplementation during a 5-day intense multiple-type exercise protocol (cf. " DHEA Blunts Muscle Damage During 5 Days of Combined Endurance, Strength and HIIT Training in Young Men "). Today, I have another interesting set of data for you - data which could not just shed some light onto the underlying mechanisms of the said protective effects against skeletal muscle damage, but also on DHEA's beneficial effe...
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DHEA Blunts Muscle Damage During 5 Days of Combined Endurance, Strength and HIIT Training in Young Men

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Image 1: Who would have thought that? Dehydroepiandrosterone (DHEA), a demystified anti-aging agent, turns out to be a potent muscle protectant in young men In the past couple of days you have learned all those "boring" things about regeneration. Taking a hot bath, training lightly, posing, isometric contractions, ... and what about supplements? The basics, which are. protein , creatine and baking soda *rofl*, are probably already part of your regimen, but would you have thought that dehydroepiandrosterone , short DHEA (not to be confused with DHA in fish oil ), the touted vitality and longevity hormone, of which the medical establishment has long concluded that there is, as in the case of most antioxidants "little evidence to suggest that DHEA replacement or supplementation prolongs life or prevents disease" ( Kamel. 2008 ) could make a valuable addition to the supplement regimen of young athletes who constantly train at the narrow margin between over-reac...
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DHEA Inhibits Fat Gain More Effectively Than Testosterone. Both Work by Reducing PPAR-γ and Thusly Lipid Storage

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Image 1: This is the "Fountain of Youth" in Karlsruhe, Germany. I have never been there, but I guess I should take the next train and check whether water contains 0.4% or 0.8% DHEA ;-) Outside of the medical practices of some anti-aging docs nobody appears to care about the "good old" dehydroepiandrosterone (DHEA), these days. As a diligent student of the SuppVersity, you are yet well aware of the reviving effects DHEA has on the liver (cf. August, 26, 2011 ), pancreas & insulin sensitivity (cf. May, 15, 2011 ) and adipocyte metabolism (cf. April, 8, 2011 ) in "older" people or everyone with suboptimal DHEA levels. You will also be aware that the adrenal steroid hormone which can be converted to testosterone (and thusly DHT or estrogen) at the target tissue exerted pretty astonishing effects on body composition in a handful of initial (very) high-dose trials. Follow up studies in the late 1990s were yet mostly unable to reproduce these encouraging...
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DHEA Revives Liver of Aged Rats and Improves Antioxidant Reserves and Akt Signaling in Young and Old Rats.

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Image 1:  I don't think celebrities realize it, but there is more to anti-aging than an unlined face. New studies show that DHEA could after all help with all sorts of age related diseases (img. antiagingpossible.com ) It's been a while since DHEA was in the news. While I have posted a handfull of mostly beneficial findings related to dehydroepitestosterone (DHEA), the hype that sourrounded its purported anti-aging effect in the late 1990s has completely abated. In view of DHEA's implication  (or rather the lack of the latter) in age-related autoimmune disease, sexual disfunction, osteoporisis, deteroiations of lipid metabolism, type 2 diabetes and cardiovascular and liver disease (Basci. 2007- ignificance of  dehydroepiandrosterone  and  dehydroepiandrosterone  sulfate  in  different  diseases), it is questionable how people beyond the age of 40, when DHEA production declines by 2% per year...
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Longterm DHEA Supplementation Improves Suboptimal Insulin Sensitivity and Induces Beneficial Changes in Body Composition and Inflammatory Markers TNF-Alpha & IL-6 in Elderly Subjects

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It has long been established that after peaking at the end of puberty, the p roduction of dehydroepiandrosterone (DHEA) steadily declines with age and approaches levels of approximately 80% in the elderly (>75y). In the late 20th century, initial studies investigating the "anti-aging" effect of the adrenal hormone DHEA provided results that appeared to confirm the hypothesis that the restauration of DHEA to youthful levels would have beneficial cognitive and metabolic effects. Many of the findings could yet not be reproduced in follow-up studies and the pharmaceutical industry soon lost interest in spending money into research on a naturally occurring and thus non-patentable compound. Consequently, expensive long-term studies such as the one ( Weiss. 2011 ) recently been published in the medical journal AGING are scarce and thus well-worth being mentioned on the SuppVersity. Figure 1: Changes in Body Weight and Body Composition Before and After 12 months of ...
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DHEA the Slimming Hormone? Study Finds: Dehydroepiandrosterone Directly Inhibits Cortisol Synthesis in Rodent Adipocytes

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After initially being hailed as the fountain of youth, the pharma-financed medical sciences dropped DHEA, when investors realized that a naturally occurring hormone would not be patentable. This and some discouraging and/or inconclusive results from long-term studies had DHEA literally disappear from the research scene for quite some time. Therefore, I am positively surprised that on the forthcoming European Congress of Endocrinology 2011 researchers from the Kobe University in Japan are going to present a paper ( Tagawa. 2011 ) that shows that there may in fact be more to the initial findings of DHEA induced weight loss than follow-up studies would have it. Tagawa et al. investigated the possible mechanism behind the weight loss effects of DHEA and found that there is a direct inhibitory effect of DHEA on glucocorticoid (re-)synthesis in adipose tissue: Using differentiated 3T3-L1 adipocytes, we demonstrated that DHEA inhibited 11β-HSD1 activity at a concentration of 1 μM within...
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DHEA Protects Rat Livers on a High Fat Diet

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First of all, rats are not a particularly good model for DHEA metabolism in human beings. Nevertheless, the results of a study by Magyar et al. ( Magyar. 2010 ) would warrant further investigations into the effectiveness of high dose DHEA supplementation on total scavenger capacity and liver fat content in men. In the course of a 28 day intervention the scientists fed rats on either a normal or a high fat diet and supplemented their drinking water with no DHEA (Control), 400µg DHEA (DHEA) and 150µg DHEA-Sulfate (DHEA-S). Table 1: Fresh frozen liver fat content, SOD, catalase and GST activity results on Day 28 As the figures in Table 1 indicate both, DHEA and DHEA-S were able to reduce the negative effect of the high fat diet on liver fat content and oxidant status (as measured by SOD-, Catalase and GST activity). This is an interesting result, of which the scientists write: Our results support the hypothesis that DHEA and DHEAS supplementation can improve the antioxidant status ...
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Are Micronized DHEA and Similar "More Bioavailable" Preparations Worth It?

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The scientifically mostly unbacked attention the micronized preparations of DHEA and Pregnenole receive all over the web raised my interest in whether the claims of higher bioavailability are warrantable. It turned out to be difficult to find conclusive answers (apart from the webpages of the producers and retailers, of course ;-), but I came up with the results of a 1996 study on the delivery of micronized preparations of dehydroepiandrosterone (DHEA) to premenopausal women [ Casson. 1996 ]. The researchers conclude: Micronization increased the area-under-the-curve ratios for dehydroepiandrosterone sulfate/dehydroepiandrosterone and dehydroepiandrosterone sulfate/testosterone. Or in other words: A significantly lower amount of DHEA is converted to androgens , upon administration as a micronized preparation (cf. Fig.3 from Casson. 1996 , to the left) . The inclusion of a lipid matrix, like some companies have it, may further potentate this effect. However, scientifical validation ...
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