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Does the Usefulness of Vitamin E Supplementation Depend on Your Activity Level? Profound Decreases in Baseline and Peak Exercise Induced DNA Damage Would Suggest So

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If you are an athlete, let's say a competitive rower who trains 3+h per day, it appears as if 400IU of vitamin E would be nothing, but beneficial. If you are a couch potato, though, even that may hamper the small hormetic response you get from taking the stairs once a week ;-) I don't know if you do remember, but it is actually not all too long ago that vitamin E was what vitamin D is known: The highly celebrated non-pharmacological savior of the ailing human race. Cancer? Heart disease? Diabetes? Alpha-tocopherol, which proved to be the most potent anti-oxidant in the tocopherol family, would solve all your problems and with its ability to "scavenge" the bad "free radicals" (sounds like a story from the Brother's Grimm, doesn't it?) it would also prolong your life expectancy. After all, those mischievous reactive oxygen species were the primary drivers of the aging process... well, today we know better. Supplemental vitamin E alone does neither ...

Oral ATP Supplementation Proves Completely Ineffective Even at Very High Doses

I think most supplement companies have hitherto given up on convincing you of the use of oral ATP supplements. About 2 month ago, I did however notice a new "high dosed" product (I cannot remember the figures out of my head, but the daily dose was far below 1.000mg) was released to be bought by the in-educated public ;-) Just to discourage you from wasting your money on any such products, here is a very recent study ( Coolen. 2010 ) on the futility of attempting to rise ATP levels via oral supplementation: Thirty-two healthy subjects were randomised to receive 0, 250, 1250 or 5000 mg ATP per d for 28 d by means of enteric-coated pellets . In addition, on days 0 and 28, all thirty-two subjects received 5000 mg ATP to determine whether prolonged administration would induce adaptations in the bioavailability of ATP. ATP supplementation for 4 weeks did not lead to changes in blood or plasma ATP concentrations. Of all ATP metabolites, only plasma uric acid levels ...
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