Posts

Showing posts with the label beta agonist

Popular topics

Show more

Cyclists & Asthma? ~20% Increased Protein Synthesis W/ Salbutamol, Another Reason its Abuse Cannot be Ignored

Written by | published on
Image
Even if it is medically indicated, there's more and more evidence that using beta-2-agonists (esp. but not exclusively orally) could provide an unfair advantage to athletes: increased protein synthesis, increased mitochondrial neogenesis, established ergogenic effects,... If you've been following the news, you will be aware that the Tour de France Champion, Chris Froome, has been busted with elevated levels of the beta-2-agonists  Salbutamol  in his blood ( learn more ). Now, we could debate forever about whether the green light Froome just got is a case of double-standards or not, but that's not the purpose of this article, anyway. Rather, I want to explain why the claim that salbutamol, officially an asthma medication, wouldn't be a worthwhile doping agent is bullshit. Learn more about Clen - / Albuterol  and safer ways to get jacked at the SuppVersity Albuterol Can Improve Glucose Metabolism The Myostatin <> Clenbuterol Connection Higenamine Use...
Read full article »

Albuterol / Salbutamol Doping Works! Cyclists Just Have to Take One Pill For a 4.1% Increase in Peak Power. Plus: Its Chronic (Ab)Use Makes Their Training More Efficient

Written by | published on
Image
Inhaling salbutamol, which is the most appropriate way to combat asthma, will not provide the same beneficial effects to athletes as taking a much higher doses pill and thus "going systemic" will (Norris. 1996; Koch. 2013) Salbutamol (INN) or "albuterol", as it is called in the US, is a short-acting β2-adrenergic receptor agonist. Just like its longer-acting brother clenbuterol, it has been developed to be used for the relief of bronchospasm in conditions such as asthma and chronic obstructive pulmonary disease; and just like its brother clenbuterol, it has been and still is abused by athletes all around the world as a doping agent. For good reasons? Well, a recent study from the University of Copenhagen would suggest just that. After all, the scientists from the Department of Nutrition, Exercise & Sports , Section of Integrated Physiology found acute and long(er) term beneficial effects of salbutamol (ab)use on peak power in their subjects, 20 male endur...
Read full article »

Higenamine: PES Introduces New "Fat Burner" to the Market. Potent Thermogenic or Dangerous Stimulant?

Written by | published on
Image
Image 1: The reformulated PES Alpha T2 contains higenamine , alpha yohimbine and 3.3-diiodo-l-thyronine I just received an advertisement email containing some information about the reformulation of PES popular fatburner Alpha T2 (make sure to read " T2 a Fat Burner for Bulking? " for some details on the thyroid stimulating properties of 3.5-diiodo-l-tyronine the metabolically more active "brother" of the 3.3.-diiodo-l-tyronine in PES Alpha T2) mentioning a compound that is advertised as "an all new beta-agonist", that would have been found to be "more effective" than synephrine. While this claim did not impress me at all, I took the time and dug up some information about "higenamine"... The adrenergic effects of higenamine ( Hig. demethylcoclaurine ) have been well established since the 1980s ( Park. 1984 ). In fact, the cardioactive benzylisoquinoline alkaloid isolated from Aconiti tuber has long been used as a cardiotoni...
Read full article »

Clenbuterol as Libido Booster? Not really...

Written by | published on
Image
Figure 1: Chemical structure of clenbuterol ( R )-Isomer (top) and ( S )-Isomer (bottom) ( wikipedia.de ) In a 1989 study Benilla et.al. (Benilla. 1989) found an astonishing effect of low (0.01mg/kg) / high (0.1mg/kg) dose clenbuterol administration to rats. Interestingly, the beta-agonistic effect of Clenbuterol increased or decreased sexual activity depending on former activity levels . For sexually vigorous rats Clenbuterol decreased the sexual activity significantly, while formerly sluggish rats on a low dose clenbuterol regimen (0.01mg/kg/day) suddenly became "serial lovers" with an increase in mount latency from a sluggish 580.3s to a horny 99.5s. Their pharmacologically improved mount latency is however is still longer than that of untreated, sexually vigorous rats (61.5s). Similarly, their postejaculation interval (462s) is still 32% above that of their naturally ruttish fellows. Bottom line: Do not try to use Clenbuterol as a Viagra replacement AND pleas...
Read full article »
Disclaimer:The information provided on this website is for informational purposes only. It is by no means intended as professional medical advice. Do not use any of the agents or freely available dietary supplements mentioned on this website without further consultation with your medical practitioner.