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Quick Take: Only 25% Putatively Anabolic Laxogenin Supps Contain Measurable Amounts of the Alleged Muscle Builder

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You may find this supplement albeit with a less honest label at your favorite 'hardcore'-supplement store. You will have seen them pop up (and already begin to disappear again) in almost every supplement store that considers itself 'hardcore' but 'natural': laxogenin supplements. By their producers and the shops that sell them corresponding products are marketed as an agent that "can help you add muscle and shed fat", that is "not classified as a prohormone", that "doesn’t need to be cycled" and that "delivers results" and targeted at natural bodybuilders and fitness enthusiasts. Read more about studies involving TRT/HRT & co on suppversity.com: What to expect from normalizing Testosterone Testosterone Gel Augments 'ur Gainz PWO T-Increases Don't Determine Your Gainz The Hormonal + Other Underpin-nings of Gainz Impressive 12% T-Boost (+20% IGF1) W/ Tribulus T +/- Exercise to Rejuvenate...
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When Hype Meets Reality: D-Aspartic Acid Turns Out to Be Another Supplemental Nonstarter in First Human Trial With Any Relevance for Healthy Young Men

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Training "on" D-Aspartic Acid is like training on guar gum. Busted! D-Aspartic acid aka DAA is another "natural anabolic agent" that turns out to be more of a revenue- than a hormone-booster with muscle building prowess. And you know what? It took Darryn S. Willoughby and Brian Leutholtz from the  Exercise and Biochemical Nutrition Lab, Human Performance, and Recreation at Baylor University exactly 28 days and 20 apparently healthy, recreationally active, resistance trained (3x per week or more in the past year) men with an average age of 22.8 ± 4.67 years (BMI 24.65 kg/m²) to prove that d-aspartic acid (DAA) supplements belong to this never-ending list of supplemental non-starters. Things that work: 28 days, 4x per week heavy resistance training; things that don't work DAA capsules Better supplement w/ "K" than with DAA - potassium (K)  (in German it's Kalium)! Potassium vs. Diet-Inducded Insulin Resis. In the Lime Light: The Ill ...
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Capsaicin or Plant Oxysterol 28-Homobrassinolide (28-HB) - Two Candidates for a Natty Test Booster that Works?

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In am not sure if people got afraid that I rip their papers apart by pointing with a figure at the non-existent real-world significance of their revolutionary findings about the testosterone boosting effects of herb X from the deepest jungle in Y. What I do know however, is that for whatever reason studies like these have become rare as of late. I have still been able to pick up two of them, to do what Carl usually calls the SuppVersity Sniff Test on Capsaicin *achoo!* ... sorry! And the oxysterol 28-Homobrassinolide, which is present in miniscule amounts in Chinese cabbage , for example. Capsaicin: The hotter, the better? The first of the two studies we are going to tackle, today, comes ri g ht from the Department of Histology & Embryology at the Faculty of Veterinary Medicin e of the University of Uludag in Turkey... and yes, the fact that it comes from the " Department of Histology & Embryology at the Faculty  of Veterinary Medicine" is in fact a first ...
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Brocebo? Add 10kg to Your Bench in Days with Sugar-Based "Anabolic Steroids". Old Study Shows, Many "Natural Anabolics" Could Work Solely via Placebo Effects

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Image 1: If you start thinking about whether or not the product you just bought at your local supplement store works, it is - for a non-negligible amount of supplements - unlikely that you will see any results (photo Scientific American ) I guess, I don't have to tell you what the term "placebo effect" stands for, right? It is the occurrence of an effect that - assuming the effect could speak - would say of itself "placebo", i.e. "I am pleasing" (1st person singular, presence active from lat. "placere", i.e."to please" ). And while the medical establishment is still arguing, whether it was feasible, and, in view of the fact that this must obviously happen unbeknown to the patient, even ethical, to deliberately exploit the placebo as a "medical" treatment strategy, there are certain supplement companies that generate up to 90% of their revenue from an allegedly muscle-packed cousin of the placebo effect, the brocebo eff...
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Ursolic Acid and The Narrow Line Between Anabolism and Myotoxicity: +25% Increased Protein Accretion in In-Vitro Study, But Cell Death With 2x "Effective" Dose

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Image 1: "An apple a day keeps the doctor away!" And though the ursolic acid in its peel may be part of the underlying mechanism, this does not make it a "natural anabolic", but rather another item on the list of "healthy stuff from real food" The number of purported natural anabolics increases year by year. Against the background that most of these products are nothing but supplemental nonstarters in shiny bottles and boxes with "non-FDA approved" promises of "unparalleled muscle growth" on them, the recent release of a broad range of ursolic acid supplements must already be considered a "highlight". With a peer-reviewed rodent studies backing its anti-catabolic, pro-anabolic properties ( Kunkel. 2011 ), it appears as if ursolic acid could be more than another potent placebo. And if we put things into perspective, in the end its potential beneficial effects on skeletal muscle hypertrophy are rather negligible compared to...
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LG Natadrol: A Short Write-Up

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A few weeks ago, LG released Natadrol , a product containing a new, self-proclaimed  "potent muscle-building androgen found naturally occurring in our environment". Sounds like an invitation for a "SuppVerSive" investigation into its somewhat exotic ingredients .* So lets see what we have here * Tinospora Cordifolia (TC) has androgenic activity, established exclusively in the prostate ( Kapur. 2009 );  lowers blood sugar ( various studies );  good for immune system ( various studies );  potent antioxidant ( Singh. 2006 );  good for the heart ( Rao. 2005 );  hypolipidemic, i.e. it lowers blood fats ( various studies ) Overall: If TC is androgenic in the prostate it might as well work as an androgen elsewhere, other than that there is no evidence that apart from being "healthy" (outside the prostate) it might in itself be anabolic . Note: LG is honest and lists it under "androgenic factor" < so their claim holds true, yet it has...
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