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MTHFR Mutations, Cardiovascular Disease, and Riboflavin (B2): Scientists Zone in on a Neglected Ménage à Trois

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You can test your MTHFR gene either directly  or by plugging your raw data from 23andme, or another provider into evaluation tools such as Genetic Genie . If you have no idea what #MTHFR means, here's the Reader's Digest version: MTHFR is an enzyme that is affected by a mutation in the MTHFR gene. The latter encodes the enzyme methylene-tetrahydrofolate reductase a ka MTHFR effectively unless there's a single-nucleotide polymorphism (SNP) affecting the 677th base pair of the MTHFR gene... not helping? Well, let's just say if you have a certain variation of this gene, you're having a hard time processing B-vitamins; and it's not totally unlikely that you're affected : According to  Marini et al. 2008 , this mutation affects 29% of the global population. Previous studies, however, report much lower estimates for prevalence of the MTHFR 677TT genotype, i.e. 10% worldwide, with values ranging from 4 to 18% in the United States, over 20% in Northern China to ...
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Vitamins B1, B2, B5 & B6 & Glucose Management | Part VII of the "There is More To Glucose Control Than Low Carb"- Series. Any Real Benefit From Supplementing With "Bs"

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Funny or obscene? A woman w/ low vitamin B and thus fortified cornflakes is among the "top images" Google will show you, when you search for B-vits There is an often overlooked reason I am addressing thiamin (B1), riboflavin (B2), panthotenic acid (B5) and pyridoxine (B6) in one installment of the "There is More to Glucose Control Than Carbohydrates"-Series (read previous installments ): They are all necessary to store glycogen in the liver (Supplee. 1942). In general, a whole foods diet, as recommended in previous SuppVersity articles will easily cover the B-vitamin needs of the average sedentary and physically active individual - in spite of minimally increased requirements for B2 & B6, in particular (Manore. 2000; Woolf. 2008). You can learn more about this topic at the SuppVersity Proteins, Peptides & Blood Glucose SFA, MUFA, PUFA & Blood Glucose Vitamin D & Diabetes Glucose Manager Calcium? Flush & No-Flush Niacin ...
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Natural Migraine Prophylaxis & Treatment: Riboflavin, ALA, Magnesium, CoQ10, Feverfew, Melatonin, Butterbur & Co.

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Natural migraine protection: Even if supps won't cure it, they can at least reduce the number of "bad days" and the severity of the attacks. In the last installment of the " Short News " you've learned about the enormous costs chronic pain produces on an annual basis: Roughly $300 billion for its treatment and another $300 billion in form of economic damage. No wonder pain killers, Cox inhibitors and & co are among the top selling and drugs in the world. Now, migraine is unquestionably among the most debilitating forms of chronic or rather cyclic chronic pain and while women are much often hit by the pain from withing (21.8% v.s 10.0% of the US citizens suffer; NHS 2009). And while I cannot tell you how much of the $2,000 bucks each of you is "spending" on an annual base on treating the pain of his / her fellow citizens, I believe that both of you, my dear mal and female readers, may benefit from the information in today's installment...
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Mitochondrial Super Food: R-ALA, Acetyl-L-Carnitine, Biotin, Nicotinamide (B3), Riboflavin (B2), Pyridoxine (B6), Creatine, CoQ10, Resveratrol & Taurine Optimize Mitochondrial Function.

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From China, the biggest (and cheapest) producer of raw materials for dietary supplements comes a study ( Sun. 2011 ) on the effectiveness of a mitochondrial nutrient combination on performance and mitochondrial biogenesis in exhaustively exercised rats, which may well have consequences on the number of items on your next supplement shopping list. For 4 weeks , Sun et al. supplemented exhaustively exercising rats with a combination of R-a-lipoic acid, acetyl-L-carnitine, biotin, nicotinamide, riboflavin, pyridoxine, creatine, CoQ10, resveratrol and taurine (cf. table 1) Table 1: Ingredients of the "mitochondrial nutrient supplement";dosage used in rat study (data adapted from Sun. 2011 ); and calculated human equivalent doses  This nutrient combination had beneficial effects on standard markers of exercise induced oxidative stress and muscular breakdown . Specifically, it "significantly inhibited the increase in activities ...
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B-Vitamins & Diabetes: Protective or Causative?

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In a very interesting study, scientists from China and Japan ( Zhou. 2010 ) found that " long-term exposure to high level of the B vitamins may be involved in the increased prevalence of obesity and diabetes in the US in the past 50 years ". At first this appears to be counterintuitive, since we have been told over and over that B-Vitamins are not only good for our health, but that we could not even "overdose" them. While the latter has been questioned for years and certainly is not the case for e.g. B6 and niacin, even the former seems questionable, if you read the results from the above mentioned study: The prevalences of diabetes and adult obesity were highly correlated with per capita consumption of niacin, thiamin and riboflavin with a 26- and 10-year lag, respectively (R2 = 0.952, 0.917 and 0.83 for diabetes, respectively, and R2  = 0.964, 0.975 and 0.935 for obesity, respectively). [...] The relationships between the diabetes or obesity prevalence and per ca...
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