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Citrulline & Glutathione - GSH Amplifies & Prolongs CIT's NO Boosting Effects During + After Biceps Workout

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From a physiological perspective NO is not primarily there to make you look vascular and pumped, boys. If you've read the headline and are asking yourselves "Why on earth would I even want to spend money on cosmetic pump?", you probably need a reminder of the multiple important functions nitric oxide (NO) serves in your body: (1) With their ability to relax the musculature of your blood vessels to increase the blood flow through your veins, normal NO levels are required to guarantee optimal blood flow to every body part; (2) since this includes your sexual organs, normal NO levels are also a prerequisite for normal / optimal sexual function; (3) having enough NO is also required to keep your immune defenses up, because the white blood cells need it in their fight against intruders; and if heart disease, sexual dysfunction and immune health are all things you don't care about (4) you may be interested to hear that your brain and metabolic health critically depend o...
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The Latest on Glutathione Supplements - Yes, They Can Work; And Yes, They May Even be Beneficial for Athletes

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Do you really need even more pills? The answer is "NO!" - even if GSH supplements actually seem to work. If you'd asked me 2 years ago, I'd answered the question whether glutathione (GSH) supplements even work with a determined "I don't think so!" Meanwhile, there have been a handful of interesting papers which indicate that oral glutathione supplements could actually work. The latest and one of the more interesting of these papers comes from the Graduate School of Life and Environmental Sciences at the K yoto Prefectural University  where Wataru Aoi et al. took the next step and tried to prove the significance of Kovacs-Nolan et al.'s (in press) and Park et al.'s (2014) finding that glutathione is intestinally absorbed and transported intact across the human intestinal epithelial wall in a rodent model and in humans. The hormesis-concept says: Antioxidants are not always good for ya! Is Vitamin E Good for the Sedentary Slob, Only? ...
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Supplement Sensation? Oral Glutathione Supplements Dose-Dependently Double GSH in Randomized Controlled Human Studies. Health Implications Still to Be Determined

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Blueberries and other foods w/ tons of polyphenols are GSH boosters (Moskaug. 2005) and make supplements obsolete.  If you have been interested in dietary supplements for some time, I am pretty sure that you will have heard about oral glutathione ob(GSH) supplements in one of the "snake oil warnings" on various websites. The "master antioxidant" as it is called is after all believed by many to be not bioavailable - at least not orally. Studies in animal models, however, have already shown that oral GSH, administered either in the diet or by gavage, has the ability to increase plasma and tissue GSH levels ( Loven. 1986; Aw. 1991; Favilli. 1997; Kariya. 2007). It would thus be more appropriate to say that the efficacy of oral glutathione in humans has not yet been tested in peer-reviewed studies. You can learn more about potential negative sides of too many / the wrong antioxidants : NAC = GSH ￪, Anabolism ￬ Too Much "Vit C" For Gains? Protei...
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Iodine Induced Reduction in Hepatic Deiodinase Activity Leads to Hypothyrodism and the Accumulation of Liver Fat That May Eventually Pave the Way to Diabesity

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While us Westerners think of goitre mostly as a result of iodine deficiency, the Chinese have learned by hard that the opposite is about as likely - goitre in response to iodine in the drinking water is a huge health problem in certain parts of the country (Zheng. 2000) As colorful as the web may have become, it is still full of paradigmatic black-and-white thinking: The world is either black or white and if you browse the blogosphere, it would appear that iodine would certainly belong to the white part of our world. That in exactly those people who are often referred to as an example of the multitude of beneficial health effects, namely the Japanese, a high intake of iodine has repeatedly been shown to be associated with low thyroid function and even full-blown hypothyroidism, on the other hand, is something you will probably not learn from the tons of unreferenced stuff you'll find on the Internet about how good, if not essential it was for your health to take copious amounts...
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3.2g of Beta Alanine Reduce Rate of Perceived Exertion, Increase Time to Exhaustion and Ventilatory Threshold. Vegetarians, Older People and Diabetics May Benefit Most.

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Image 1: If you are into running, ladies, beta alanine is for you ;-) Those of you who make sure that they are getting their highly educative daily dose of the SuppVersity *rofl* will be aware that today's blogpost is, once again, dealing with beta alanine. Contrary to yesterday's post , which dealt with its pharmacokinetics, we are today going to have another look at what kind of real world performance outcomes the average (female!) physical culturist can expect from taking at least 3.2g of the beta amino acid per day - a dosage that has been shown in previous studies to increase intra-muscular carnosine levels by 27–39% in fast- and slow-twitch muscle fibers, respectively ( Baguet. 2009 ). And though I do not want to spoil things, I can already tell you that the results make it quite clear why beta alanine is not the next creatine . Somehow ergogenic, yet not really antioxidant For the study that was conducted at the Applied Physiology Laboratory at the University ...
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Inflammation Is a True Fat Burner: BSO-Induced Glutathione Depletion Wards off Fat Gains on Hypercaloric Diet

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Image 1: This little bugger obviously has too little inflammation going on ;-) Are you "on fire"? Inflammation has been implicated as the root cause of almost all modern disease: obesity, diabetes, heart disease, cancer, you name it. Soothing the flames via natural and supplemental anti-oxidants has thusly been proposed and marketed as a solution for many of the aforementioned health problems. Yet, despite tons of vitamins, anti-oxidants and all the other "healthy" stuff we are taking and consuming on a daily basis, the number of morbidly obese people, diabetics and heart attack patients appears to be ever-increasing... how can that be? A possible answer to that question comes from scientists from the Saha Cardiovascular Research Center at the University of Kentucky College of Medicine in Lexington, Kentucky, US ( Findeisen. 2011 ) - we simply got everything wrong ! The observation that insulin resistance and beta-cell dysfunction usually occur in...
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Rodent Study Suggests: Selenium, Nature's Neuronal Corrosion Inhibitor Could Protect the Brains of Hard Training Athletes from Oxidative Damage.

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Image 1: Selenium is a naturally occurring mineral involved in a host of metabolic processes. Are you a hard training athlete? A weekend warrior? Marathon runner? Or just an an average fitness-enthusiast? Yes? Did you ever think about what an exhausting workout, let alone arduous marathon running may do to your brain? No? Then it may come as a surprise to you that other than regular moderate physical exercise, which has repeatedly been shown to exert beneficial effects on mental and physical development, intense exercise precipitates oxidative stress not only in the working muscle groups, but within your whole body - including your brain, where the exercise-induced increase in free-radicals may dramatically increase lipid oxidation ( Goldfarb.1996 ; Kanter. 1998 ). Based on observations with other antioxidants and the well-established involvement of selenium in the activation of the master-antioxidant glutathion , researchers from the Selcuk University in Konya, Turke...
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