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Synephrine More Ergogenic, Than Thermogenic? Pump Supps Revisited - L-Arginine, L-Citrulline and Respective Whey-Peptides & -Nitrates | ISSN Research Review '15 #2

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Synephrine, arginine, citrulline - Which pre-workout ensures that you're "on fire"? As I pointed out previously , my initial idea to cherry pick only the most interesting study results that were presented in form of of poster presentations at the Twelfth International Society of Sports Nutrition (ISSN) Conference and Expo in 2015 didn't work out. The number of interesting studies is is simply too much for a single SuppVersity  article to discuss them all. Accordingly, I am now posting the 2nd serving of what is going to be a multi-part series of articles with brief discussions of the most significant results of the >20 studies and short references to those that didn't make the SuppVersity  cut in this, previous and future installments of this series for one reason or another. Read more about ISSN and other studies at the SuppVersity Vitargo, Red Bull, Creatine & More | ISSN'15 #1 Pump Supps & Synephrine & X | ISSN'15 #2 Hi...
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Are You Afraid that the Fructose Boogieman Clogs Up Your Liver? Citrulline or Alanine, Glycine, Proline, Histidine and Aspartate Mix Will Protect You + Maybe Lean You Out

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If you belong to the people who simply cannot stay away from HFCS foods and beverages, you may be happy to hear that the equivalent of as little as 10g citrulline or NEAAs in your diet may do much more than "just" fully prevent its negative effects on your liver. You will probably remember from previous articles I wrote that NAFLD, or rather the development of non-alcoholic fatty liver disease, is one of the earliest markers of metabolic syndrome and beginning type II diabetes. In the Western obesity societies in North America and Europe, NAFLD is among the most common causes of chronic liver disease and its prevalence is increasing rampantly (Marchesini. 2001). In spite of the fact that its development is most strongly linked to the consumption of a generally unhealthy, energetically dense diet, there are several lines of evidence which suggest that the ingestion of exorbitant amounts of fast-digesting fructose from high fructose corn syrup (HFCS) sweetened beverages ...
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Citrulline = The Dieter's Amino Acid? Citrulline Maintains Muscle Protein Synthesis & Strength Endurance During Caloric Deficits Better Than Leucine!?

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Can citrulline supplementation prevent you from hitting a catabolic wall, when you are dieting? And is it more potent than leucine? You have been told "leucine is the most anabolic amino acid known to man", by the guy at your local GNC, the bros in the gym and the "experts" on the board. And yeah, in a way, they all are "right", but the surprising negative effects of HMB supplementation on the muscle catabolism during overtraining ( read more ) should have reminded you that this does not imply that it will also protect your muscles against muscle breakdown and/or have similar "anabolic" effects on a diet. Dieting is a major change in the metabolic stage and another stage means a different cast, among whom citrulline could turn out to be the new star... at least if we trust the results of a recent rodent study. Different metabolic stage - new stars on the scene In their most recent paper Ventura et al. describe the results of a rodents...
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Leucine, Citrulline or a Non-Essential Amino Acid Mix - Which Amino Acid(s) are Most Effective in Preventing Muscle Loss During an 18h (Intermittent) Fast?

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Image 1: If Chris, "the Techician", Aceto's usually well-informed sources are right and the former Mr Olympia Jay Cutler is currently trying to lose muscle (I heard him say that on Heavy Muscle Radio ), Cutler would be ill advised if he ingested ~20g of non-essential amino acids during and / or in-between extended fasts and hours of arduous low-intensity cardio sessions (img  MuscleTech ) Those of you who followed the " Amino Acids for Super Humans " series I did earlier this year on Carl Lanore's Super Human Radio may remember the arginine < > citrulline < > ornitine cycle and how I tried to explain that, from a physiological perspective, arginine's role in ammonia detox is probably as, if not more important than its role in the production of nitric oxide. What most of you will probably have overheard, or, in the respective shownotes, over-read, was my reference to a 2006 study from the University of Paris , which was - at least to my ...
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L-Citrulline Improves Sexual Performance: 50% Chance of Improvement with just 1.5g/day

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You probably receive the same amount of daily spam mails trying to refer you to dubious viagra retailers somewhere on the Cayman Islands, or wherever else in the world. In case, you ever even thought about ordering stuff like that, you may as well consider getting some l-citrulline from your local supplement store first. Scientistsfrom the University of Foggia in Italy ( Cormio. 2011 ) have found that supplementation with as little as 1.5g/day l-citrulline improved erection hardness in men with mild erectile dysfunction (and I always thought Italian men would not have any erection problems ;-): Significant improvement in the EHS [erection hardness score] from 3 to 4 was reported by 2 (8.3%) of the 24 men when taking the placebo and 12 (50%) of the 24 men when taking L-citrulline ( P < .01). The mean number of intercourses per month, a nonvalidated patient-reported outcome we have commonly used in patients treated for ED, was 1.37 ± 0.93 at baseline, 1.53 ± 1.00 at the en...
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L-Citrulline Against Arterial Stiffness

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You probably know it from the ingredient list of your pre-workout or amino acid product , l-citrulline . Being a possible precursor of l-arginine it is included in those formulas to increase nitric oxide levels and deliver those "skin bursting pumps" the advertisements brag about. In a recent study, scientists from Japan ( Ochiai. 2010 ) found that 1 week of l-citrulline supplementation at 5.6g/day effectively reduced arterial stiffness in 15 healthy males: Compared with the placebo group, baPWV [ index of arterial stiffness] was significantly reduced in the l-citrulline group (p<0.01). No significant differences in blood pressure (BP) were found between the two groups, and no correlation was observed between BP and baPWV. The serum nitrogen oxide (NOx, the sum of nitrite plus nitrate) and NO metabolic products were significantly increased only in the l-citrulline group (p<0.05). Plasma citrulline, arginine and the ratio of arginine/asymmetric dimethylarg...
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