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High Fish Oil Diet ➯ N3-Oxidation ➯ Fat Cell 'Aging', Plus Neuronal Damage | 12+ Studies to Contextualize the Results

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Athletes could be at particular risk of 'going rancid' You will probably remember both my previous article about the "rancidity" problem with over-the-counter fish oil products (see "3/3 TOP-Selling US Fish Oils Exceed Maximal Peroxide and Total Oxidation Levels - Levels Roughly 4000% Higher Than in Medical Grade N3 Supplements, Harvard Study Shows" | read more ), as well as my often-phrased general skepticism about the usefulness of high dose (>1-2g/d) fish oil supplements. You can learn more about omega-3 & co. at the SuppVersity Krill vs. Fish Oil - Is one Better? How to Avoid N3 Oxidation N3/N6 Ratio Doesn't Matter!? MUFA & Fish Oil Don't Match Fish Oil Doesn't Help Lose Weight Rancid Fish Bad 4 Health Back in the day, I already mentioned that the evidence on whether and how detrimental the consumption of (partly) oxidized fish oil actually is 'skinny' to say the least. As researchers from the U...
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How Working Out Changes the Morphology of Your Body Fat and Why This Explains that Intensity and Explosiveness Hold the Key to Getting and Staying Lean, Fit and Healthy

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Can the guy on the right run away from the bloated macrophage coated fat cells on the left? Today's first post in the SuppVersity Exercise Science Week does hold the answer to this existential question. Those of you who don't just read, but also think about the headlines of these posts will probably already have theorized about the remote possibility that I could have changed my mind and discarded the original plan to do an "exercise quickie" early this week (see SuppVersity post from Saturday ). Now, before you are getting mad at me, let me give you the (as I would say good) reason for doing that: Some, if not almost all of the exercise related studies, I have piled up here are actually too interesting to end up as part of a mash-up. That's particularly true in view of the fact that my time budget during the week does not allow me to discuss them in appropriate detail. So, even if wanted to end up writing >10,000 word posts, this would only work on 48h da...
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Phospholipid or Triglyceride? What's in Your Fish Oil Caps? Only Phospholipid Based DHA+EPA Reduces Fat Cell Growth & Elevated Insulin Levels Despite Obesogenic Diet

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Image 1 (Liliyu. 2007): Look no further, DHA+EPA in phospholipid form can be found right around the corner in the salmon-sashimi at your favorite sushi restaurant, for example. I guess you will already have heard about the "huge quality differences" of different fish oil products, the manufacturers of the more expensive products usually use to justify the price difference to the average no-name fish oil cap from your favorite bulk supplier. You may also remember a previous SuppVersity post on the obviously over-blown problem with oxidized (=rancid) fish oil (see " Some Things Fishy: Oxidized Fish Oil Totally Benign!? "), which - much to the researchers' own surprise, worked just as well as regular, fresh fish oil (Ottestad. 2011). What you will probably not have thought about before, however, is the triglyceride to phospholipid ratio of your fish oil caps (Note: While there are intact phospholipids in raw or barely cooked fish, it is almost certain that mos...
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The Leptin-Ilex!? Does Yerba Mate (Ilex Paraguariensis) Restore Leptin Sensitivity or Does it "Just" Help You Lose Body Fat by Curbing Your Appetite?

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Image 1: Mate tea, which is made of the dried leaves and twigs of Ilex paraguariensis, a shrub or small tree native to subtropical South America, has long been touted as a useful weight loss tool (img Ilosuna, Wikipedia ) Isn't it funny, how complicated losing weight has become? I mean, only 20 years ago the one thing you had to do, to lose weight was eat less and (optionally) exercise more. These days, a calorie is not a calorie anymore, the bad fats are good, the good carbs are bad and still neither of those are created equal. And as if watching your blood lipids and glucose levels was not enough, you also have to keep an eye on your leptin levels, these days. In this utter confusion the main message of a study Young-Rye Kang and his colleagues recently published in the Journal of Laboratory Animal Science appears far too simple to be true ( Kang. 2012 ): Fat rodents who reduce their calorie intake back to normal lose all their superfluous body fat within 4 weeks. That this h...
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DHEA Inhibits Fat Gain More Effectively Than Testosterone. Both Work by Reducing PPAR-γ and Thusly Lipid Storage

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Image 1: This is the "Fountain of Youth" in Karlsruhe, Germany. I have never been there, but I guess I should take the next train and check whether water contains 0.4% or 0.8% DHEA ;-) Outside of the medical practices of some anti-aging docs nobody appears to care about the "good old" dehydroepiandrosterone (DHEA), these days. As a diligent student of the SuppVersity, you are yet well aware of the reviving effects DHEA has on the liver (cf. August, 26, 2011 ), pancreas & insulin sensitivity (cf. May, 15, 2011 ) and adipocyte metabolism (cf. April, 8, 2011 ) in "older" people or everyone with suboptimal DHEA levels. You will also be aware that the adrenal steroid hormone which can be converted to testosterone (and thusly DHT or estrogen) at the target tissue exerted pretty astonishing effects on body composition in a handful of initial (very) high-dose trials. Follow up studies in the late 1990s were yet mostly unable to reproduce these encouraging...
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