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Beta-Alanine vs. L-Taurine: Study Establishes Inverse Relationship

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Image 1: Beta alanine It is not new that there exists an antagonistic relationship between muscle carnosine (M-Carn, which is increased via beta-alanine supplementation), on the one hand, and muscle taurine (M-Tau) levels on the other.  The study by Harris, et.al. (Harris. 2010) is however the first to report on the immediate effect of supplementing with 2x800mg of a time-released beta-alanine (structure, cf. image 1 on the right. HMDB v2.5 ) formula on muscle taurine content in seven male subjects after four weeks of daily supplementation. A realistic scenario as these dosages can be found both in stand-alone, as well as an kitchen-sink approach supplements such as NO-Xplode & Co : Pre and post supplementation M-Carn was 25.9 ± 4.3 and 41.3 ± 5.5 mmol.kg -1 dry muscle and M-Tau 28.1 ± 7.1 and 22.6 ± 7.0 mmol.kg -1 dry muscle . Despite the 20% fall in M-Tau , values of M-Tau remained within the normal physiological range . Before supplementation M-Tau was negative...

Glutamine: Alanyl-Glutamine or L-Alanine + L-Glutamine - Is There a Difference?

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Some athletes, mostly bodybuilders, swear by it, yet the results of studies on the ergogenic effect of l-glutamine supplementation are quite unequivocal. A recent study ( Petry. 2010 ) investigated the effect of alanyl-glutamine (DIP, at 1.5 g/kg, n=8) , L-glutamine + L-alanine (GLN+ALA, at 1 and 0.61 g/kg, respectively; n=8 ) or water (CONTR, n=8 ) supplementation on various exercise-related parameters in rats after 21 days of training. The results are promising, yet far from earth-shattering: "Supplementation with DIP or GLN+ALA increased plasma glutamine concentration by 23% and 21% respectively , as compared to CONTR group (p<0.0001). Plasma ammonia concentration was lower in both supplemented groups (DIP, 3.8 ± 0.1 μM and GLN+ALA, 4.1 ± 0.2 μM), compared with CONTR group (5.3 ± 0.2 μM) (p<0.0001). DIP and GLN+ALA groups exhibited in the soleus muscle high glutamine (33.4% and 28%), glutamate (21.7% and 10.8%) and glutathione (GSH, 52.2% and 48.4%), compar...
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