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Tryptophan, an Overlooked Natural "Anabolic"? Increased Follistatin (Myostatin Inhibitor), mTOR, and IGF-1 In-Vitro and In-Vivo Shed a Whole New Light on Serotonin Precursor

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Poultry is high in tryptophan and so is spirulina, cod, soy beans, parmesan and pork. They all have higher tryptophan contents than turkey. So, it doesn't always have to be poultry ;-) As a SuppVersity  reader you know that "[n]utrition plays a key role in the maintenance of muscle and bone mass, and dietary protein deficiency has in particular been associated with catabolism of both muscle and bone tissue" (Dukes. 2015). You will also be aware that leucine and some other amino acids play a particularly important role in the accrual and maintenance of muscle mass. Until today, l-tryptophan, the amino acid the "happy neurotransmitter" serotonin is not among the usual suspects when it comes to building muscle. If the results of a recent study from the Georgia Regents Univ.  translate into practic-ally relevant research, this may change soon (Dukes. 2015). Learn more about amino acid and BCAA supplements at the SuppVersity Glutamine Helps W/ Diabetes...
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L-Tryptophan is Reduced While Dieting - Does This Make the Essential Amino Acid a Key to Successful Weight Loss?

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Trp and it's metabolite 5-HTP may be particularly useful for female sugar cravings and binges. Can l-tryptophan help you lose body fat? If you look at the results of the latest study from the University for Health Sciences, Medical Informatics and Technology it would seem that the answer to this question may be "Possibly, yes, but..." Before we come to the implications I would yet like to take a closer look at said study which shows that a lack of tryptophan (Trp) during diets does not just affect the biosynthesis of serotonin, but may also be associated with increased susceptibility for mood disturbances and carbohydrate craving. Accordingly, "strategies to supplement Trp while dieting could be highly useful in treating uncontrolled weight gain or in preventing neuropsychiatric symptoms" (Strasser. 2014). Honestly, fasting and eating / skipping breakfast may be more promising weight loss tools Breakfast and Circadian Rhythm Does Meal Timing Mat...
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Science Round-Up Seconds - GABA & Exercise: Both Can Improve and Mess With Your Sleep. Plus: Natural GABA Alternatives and Sleep As An Overtraining-Gauge

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Don't forget that and prioritize proper sleep hygiene over pills and powders. Let me make get this straight, yesterday's episode (please note that at the minute I post this article, the download is not yet working, should go up within the next hour, though) of the Science Round-Up on Super Human Radio was not only ultra-long (120min+), it was also largely speculative. If you already listened to the show, you will know that Carl and I took up on a discussion Dan Rollins triggered on his, Carl's and my Facebook page(s). Contrary to what you would expects Dan felt that gamma-Aminobutyric acid aka GABA would not help him calm down and let him sleep. For him GABA turned out to have stimulative rather than sedative effects. I am not going to repeat all the potential explanations I went through in the first ~40min of the show here. Instead, I'd suggest you simply download the podcast and listen to the various hypothesis which range from (a) the general issue of wh...
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Pardoxical: L-tryptophan Supplementation Increases Time to Exhaustion

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Molecular structure of l-tryptophan ( HMDB v2.5 ) In view of the generally accepted paradigm that BCAA supplementation exerts its beneficial effects on exercise performance partly via counteracting the rise of tryptophan levels ( Castell. 1999 ) it appears highly counter-intuitive that L-tryptophan supplementation can decrease fatigue perception during an aerobic exercise with supramaximal intercalated anaerobic bouts in young healthy men ( Javierre. 2010 ). Notwithstanding, Javierre et. al. found that supplementation of the serotonine precursor l-tryptophan increased time to exhaustion in consecutive submaximal exercise on a cycle ergometer at 50% of the participants respective VO2max for 10 min: The total exercise time was 49.4% greater after receiving L-tryptophan than after receiving the placebo. A lower rate of perceived exertion was exhibited by the group while on tryptophan although the differences from the control group were not statistically significant. No differe...
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