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More Evidence That Myostatin is an Important Inhibitor of Diet and Exercise Induced Muscle Gains in You & Me

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Is myostatin relevant for mass monsters only, or for normal trainees, as well ? We all know the freakish images of myostatin negative animals. We all know about the heavily marketed, but scientifically not proven myostatin inhibitors. But do we also know that myostatin is actually a major inhibitor of skeletal muscle growth in the average trainee? I am not sure, but a recent study from the University of Padova  provides further evidence that the muscle hypertrophy break myostatin may in fact be what keeps you from making the same gains you saw, when you first hit the weights (Paoli. 2015). BFR and Hypoxia Training  may decrease myostatin (Laurentino. 2012). BFR, Cortisol & GH Responses BFR - Where are we now? Hypoxia + HIIT = Win? BFR for Injured Athletes Strength ⇧ | Size ⇩ w/ BFR Training & Living in Hypoxia In said study, Antonio Paoli et al. recruited 18 male volunteers, human movement science undergraduate students (age = 24.9 +/-...
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Intermittent Thoughts on Building Muscle: The Skeletal Muscle Hypertrophy 101 - Part 2: Getting Big Means Growing Beyond Temporary Physiological Limits.

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Image 1: This is another type of "dysfunctional muscle"; distinct from the one we are talking about, here Although I assume that you all have read the last installment of the Intermittent Thoughts, I took FatFree's comment that he (or she?) was missing the " too comlicated check box" from the old design to the heart (I do so with every comment, btw, so keep them coming) and kick off today's installment of "The Thoughts" with a brief and even more "dumbed down" summary of what we have learned about the (possibly) ascertained and, even if human skeletal muscle hyperplasia existed, dominant factors in the trinity of skeletal muscle growth: Protein synthestic increases in myonuclear domain sizes and the satellite cell driven incorporation of new myonuclei. Getting big goes beyond ballooning up You probably will remember the balloon-metaphor, I introduced in the red infobox toward the end of the last installment . Let's briefly...
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Intermittent Thoughts on Building Muscle: The Skeletal Muscle Hypertrophy 101 - Part 1: What is Hypertrophy?

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Image 1: Governator, Arnold Schwarzenegger, as a teen and in his early twenties. What - puberty aside - were the underlying mechanisms of the obvious increase in sleeve-size? I mean on a strictly myocellular level, of course ;-) Those of you, who have been following the Intermittent Thoughts series over the last weeks will probably already have realized that I finally dropped the "Intermittent Fasting" from the title ... this is something I have been thinking about for quite some time now. After all, the series has evolved way beyond its initial focus on a specific dietary protocol and has become more of an educational " how do you find your way to success "-series. With the format, intermittent thoughts , being still the same, the upcoming posts in this series, which will certainly touch on the topic of intermittent fasting, again, will be titled "Intermittent Thoughts on..." whatever the topic of the week may be ... and for this week's insta...
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