Caffeine & Creatine - Synergists, not Antagonists!? RCT: "Caffeine Potentiates Effects of Creatine" on Torque (+68%)
If you're looking for the extra-kick in leg workouts, the combination of caffeine and creatine may be just what you need. You will remember that I wrote about the results of Trexel's dissertation from 2015 and that his experimental evidence (real-world) refutes the previously postulated negative feedback of caffeine on the effect of creatine monohydrate on phosphocreatine stores (and thus logically on performance). Against that background, I question to which extent Vandenberghe et al. (36) were right, when they postulated that the interaction between caffeine and creatine can reduce the creatine supply and the pharmacokinetics, it has also IMHO not been proven that caffeine would impair protein synthesis by depleting intracellular calcium that changes the fatigue process but damages protein synthesis. In fact caffeine, there's more recent evidence from Moore et al. (2017) which shows that this is another theory-based hypothesis that cannot be observed in the re...