Posts

Showing posts with the label androstenediol

Popular topics

Show more

Science Round Up Seconds: 30-60% More Testosterone w/ 2.5g D-Aspartic Acid in Fertility Trial and Nicotine Amplifies Cardiotoxic Effects of ECA. Plus: Data on DHEA & Estrogen & Breast Cancer, Fermented Teas, AMPK, AKT & Co

Written by | published on
Image
DAA is probably not going to hurt your heart, but it's more likely to father a child than to build those abs. Ephedrine & Caffeine on the other hand, could help you get there, but esp. if you are also smoking you are increasing the risk that the kids you fathered using DAA will soon be without their begetter. I guess most of all will have listened to the podcast of yesterday's installment of the SuppVersity Science Round Up already. If you didn't you have been missing Carl and me discuss new on the pro-carcinogenic effects of aspartame , the never-ending story of the fattening artificial sweeteners , the benefits of oat beta-glucans for weightloss, -maintenance and gut health, the way sorghum proanthocyanidins can lower the GI of carbohydrates and make them less susceptible to enzymatic breakdown in the small intestine, and more. Actually this more, i.e. the news on DHEA, its metabolits and their proliferative effect on breast cancer cells, as well as the info...
Read full article »

Less Than 15mg of DHEA Exert Identical Beneficial Effects on Insulin Sensitivity as 1h of Cardio 5x Per Week. Both Effects Mediated Via Increases in Intra-Muscular DHT

Written by | published on
Image
Image 1: It has long been established that diabetics have particularly low DHEA levels ( Loviselli. 1994 ), but what's the chicken and what's the egg here? It is quite funny, sometimes you don't hear about certain supplements, (pro-)hormones, exercise-modalities etc. in years and then, all of a sudden, there are two studies on the respective topic in one week; and moreover, two pretty interesting ones! Last Friday, exactly 7 days ago, you've read here at the SuppVersity about the muscle-protective effects of low-dose dehydroepiandrosterone (DHEA) supplementation during a 5-day intense multiple-type exercise protocol (cf. " DHEA Blunts Muscle Damage During 5 Days of Combined Endurance, Strength and HIIT Training in Young Men "). Today, I have another interesting set of data for you - data which could not just shed some light onto the underlying mechanisms of the said protective effects against skeletal muscle damage, but also on DHEA's beneficial effe...
Read full article »

Androstenedione, Grand Daddy of All Prohormones: Carcinogenic Poison or Non-Toxic Muscle Builder?

Written by | published on
Image
I suspect you have already read statements like " prohormones will kill your liver ", "prohormones will give you gyno" and/or " prohormones will induce prostate cancer ", haven't you? Well, Androstenedione is not methylated, so bro-science would tell you that your liver won't take a beating. Yet, all gynecomastia issues aside, what if its not the methyl-group but the prohormone itself that is liver toxic or carcinogenic? A recent study published in the journal of Food and Chemical Toxicology on May 30 2011 ( Blystone. 2011 ) sheds some light onto potential side effects of the "grand daddy of all prohormones". Chard R. Blystone and his colleagues administered  "subchronic" doses of androstenedione @ 10, 20, or 50 mg/kg body weight to male and @ 2, 10, or 50 female mice. And they did that for two years . Figure 1: Cancer risk of male F344/N rats after 2 years of chronic exposure t...
Read full article »

DHEA: Overlooked or Overrated?

Written by | published on
Image
With DHEA (structure of DHEA-S, see image on the right; HMDB. V2.5 ) having been mentioned in a few of the last posts as a precursor to other androgens, I thought it might be interesting to have a brief look at the effect of DHEA supplementation on mood, body composition, sex life and human endocrine balance. Lately, a 1988 study by Nestler et.al. ( Nestler. 1988 ) has caught my attention. The researchers investigated the effect of 28 days of 1600mg/day (no, this is no typo) orally supplemented DHEA in 5 normal men (+5 men on placebo). The results were simply amazing. Apart from a 2.5x-3.5x increase in DHEA-levels, the researchers found: "In the DHEA group the mean percent body fat decreased by 31% , with no change in weight. This suggests that the reduction in fat mass was coupled with an increase in muscle mass ." ( Nestler. 1988 ) In addition mean serum low density lipoprotein cholesterol decreased by 7.5% (3.21 +/- 0.11 vs. 2.97 +/- 0.14 nmol/L; P less than 0.01...
Read full article »
Disclaimer:The information provided on this website is for informational purposes only. It is by no means intended as professional medical advice. Do not use any of the agents or freely available dietary supplements mentioned on this website without further consultation with your medical practitioner.