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Coffee Lengthens, While Caffeine Shortens Your Telomeres: An Essential Paradox? The Latest Evidence Reviewed

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If life "begins with coffee", will it also help you end later with coffee? If you follow the SuppVersity on Facebook, you will be aware that the majority of studies indicates that the chronic consumption of coffee (even in amounts of 5+cups/day) has potent health benefits - at least in normal, healthy individuals. Accordingly, you may not consider the observation Larry Tucker (2017) made when he evaluated the relationship between caffeine intake and coffee consumption and leukocyte telomere length, in his latest study surprising. After all, a drink with overall beneficial effects on one's health, shouldn't have negative effects on our telomere length, a biomarker of the senescence of cells. You can learn more about coffee and caffeine at the SuppVersity For Caffeine, Timing Matters! 45 Min or More? Caffeine Helps When Taken Intra-Workout, too Coffee can Help You Get into Ketosis Caffeine's Effect on Testosterone, Estrogen & SHBG The Co...

Will Glucosamine Make Us Live Forever? Probably Not, But in Mice the Low-Carb Mimetic Effects Make 10% Possible - In Humans, This Would be ~9 Years! Too Good to Be TRUE?

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One of the lead scientists is so convinced that the 10% life-extension the resear- chers observed in rodents will occur in humans, as well, that he is already taking glucosamine supps everyday! Next to not eating at all, not eating any carbs has recently become all the rage in the "how do extend the lifespan of stupid worms"-research all over the world. Now, I am all for eating less carbohydrates than the people who came up with "Your Plate", my American friends consider optimal. Yes! I am even in for skipping carbs altogether, but not for a lifetime (!) which is what would be necessary to reproduce the life-extending effects Schulz et al. observed in their 2007 study on the effects of carbohydrate restriction on the lifespan of the notorious (not B.I.G but) B.I.R. as in "big bad roundworm" (Schulz. 2007). You can learn more about hormesis & life extension at the SuppVersity Blocking Inflammation = Choking the Fite NAC = Reduced Dama...

Soccer Molecule of Youth? Fullerene C60 Increases Lifespan by +90% and Protects Against Free Radicals

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Image 1: Fullerenes are carbon molecules with a specific symmetrical structure; the Buckminster fullerene C60 , for example, which is made of 20 hexagons and 12 pentagons, with a carbon atom at the vertices of each polygon and a bond along each polygon edge looks like a soccer ball (img. Bryn C .) I must confess, this is not the "usual" SuppVersity news, but after making sure that the paper was not published on April, 1st, I thought that it is more than worth sharing; and that despite the fact that I am not aware of any Buckminster fullerene (C60, cf. image 1 ) olive oil solutions being sold at your local GNC... well, at least not as of yet. The earliest studies on the biological and pharmacological properties of [60]fullerene, as the "correct" notation for the "soccer ball-ish" Buckminster fullerene would be, date back to the early 1990. Despite its established usefulness in DNA cleavage, imaging, UV and radioprotection, as well as its antivira...

Tune Your Brain With Creatinyl Amino Acids: "Neuro-Ergogenic" New Wonder-Creatines Readily Pass the Blood Blain Barrier and Are Potential Candidates for Treatment and Prevention of Stroke.

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Image 1: Photograph of acute MCA stroke. Image taken at autopsy on 10-24-2006 [MODIFIED BACKGROUND]; photographer Marvin 101 @ Wikipedia.org Alpha-methylguanidino acetic acid, is an amino acid, everyone of you will be familiar with: creatine. And though this may not be the first time you will have heard of its beneficial effect on brain health, the synthesis of new forms of creatine, so called creatinyl amino acids by guanidinylation of sarcosyl peptides or creatine p-toluenesulfonate [both reactive processes in the course of which the new creatinyl amino acid is formed] appears to offer exciting new possibilities for creatine derivates in the prevention and treatment of stroke and other neurological pathologies. In a paper, recently published in the official Journal of the European Peptide Society, Peptide Science , Burov et al. ( Burov. 2011 ) describe the synthesis and possible use of advanced hydrophobic creatine hybrids...

Longterm DHEA Supplementation Improves Suboptimal Insulin Sensitivity and Induces Beneficial Changes in Body Composition and Inflammatory Markers TNF-Alpha & IL-6 in Elderly Subjects

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It has long been established that after peaking at the end of puberty, the p roduction of dehydroepiandrosterone (DHEA) steadily declines with age and approaches levels of approximately 80% in the elderly (>75y). In the late 20th century, initial studies investigating the "anti-aging" effect of the adrenal hormone DHEA provided results that appeared to confirm the hypothesis that the restauration of DHEA to youthful levels would have beneficial cognitive and metabolic effects. Many of the findings could yet not be reproduced in follow-up studies and the pharmaceutical industry soon lost interest in spending money into research on a naturally occurring and thus non-patentable compound. Consequently, expensive long-term studies such as the one ( Weiss. 2011 ) recently been published in the medical journal AGING are scarce and thus well-worth being mentioned on the SuppVersity. Figure 1: Changes in Body Weight and Body Composition Before and After 12 months of ...
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