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Melatonin As Potent as Letrozole in Inhibiting Aromatization of Testosterone to Estrogen - This Raises the Question: Is a Lack of / Bad Sleep to Blame for Breast Cancer?!

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Sleeping for 7-8h w/out interruption in a pitch black room to max. your melatonin is the best breast cancer prevention. It may sound hilarious to the next best average Joe, but the study results Suthat Chottanap and colleagues from the Chulabhorn Graduate Institute are about to present in one of the next issues of Toxicology in Vitro confirm what SuppVersity readers already knew: It's more than likely that there is a direct link between a lack of quality sleep as people who are working shift works have it and the risk of breast cancer. The latter increases in women who do not sleep during the period of the night when melatonin levels are typically at their highest by ~14% (Davis. 2011), an observation that appears only logical in view of what I am about to tell you today. You can learn more about sleep and the circadian rhythm at the SuppVersity Sunlight, Bluelight, Backlight and Your Clock Sunlight a La Carte: "Hack" Your Rhythm Breaking the Fast to...
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TReaTing Diabesity With Testosterone!? If You Keep DHT in Check + Stay Away From Aromatase Inhibitors, It May Work

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It probably won't turn an overweight pre-diabetic into a fitness model, but a getting a TRT script has the potential of changing a man's physical and psychological health for the better. Despite the fact that more and more men recognize the benefits of supervised testosterone replacement therapy (TRT) and the bodybuilding and fitness community cherishes 'their BIG T' as the be-all-and-end-all, many medical practitioners look at the administration of exogenous androgens as a potential health hazard. I would even bet that it won't be difficult to find one or two MDs who would say that Patricia S. Juang et al.'s idea to administer testosterone to obese men with normal, but low baseline testosterone levels to improve their body composition and insulin sensitivity borders physical injury - and that irrespective of adjuvant 5α-reductase (dutasteride) or aromatase (anastrazole) inhibitor administration. TRT w/ or w/out aromatase or 5α-reductase inhibitor? It ...
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T-Gel with or Without an Aromatase Inhibitor? If You Are Healthy & Lean and Want to Stay This Way, There is Only One Answer: T-Gel Without Aromatase Inhibitor!

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Don't let her talk you into participating in studies that risk your manliness ;-) Would you be willing to participate in a study, where you could end up without testosterone? No? Well me neither... strangely Joel S. Finkelstein et al. were able to find 198 healthy men between 20 and 50 years who were stupid enough to participate in an experiment, where they were randomized to placebo, or testosterone gel (1.25, 2.5, 5, or 10g per day) while being on gosererelin acetate , which did suppress their natural testosterone production. With additional 202 subjects receiving an identical "treatment", but in this case alongside a whoppy dose of the aromatase inhibitor anastrazol as a bonus, the study design leaves us with plenty of groups and tons of subjects. To "determine the relative degree of testosterone deficiency, estradiol defi­ciency, or both at which undesirable changes in body composition, strength, and sexual function begin to occur." (Finkelstein 2013) ...
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Chest Fat, Bitch Tits, Chesticles, Gynecomastia, Lipomastia and Co.: Infinite Ways to Name it, Only 5 to Get Rid of It

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Image 1: Is it what he eats, is it what he drinks or is it just  andropause? Whatever it may be, Jack does not have the "classic gyno". In the last installment of this two-part series on gynecomastia, lipomastia and co. we have seen that the number of appellations this common, mostly benign enlargement of the male breast has been given, is easily outnumbered by the potential, mostly pharmacological, but also supplemental and/or dietary factors which have been implicated in its development. In a recent paper, Krysiak and Okopien estimate the incidence of mild proliferation of the glandular breast tissue to 30%-50% of the male population ( Krysiak. 2012 ). Against that background, the universal ignorance towards the profound psychological effects, as well as the tacit acceptance that, breasts or no breasts, "men don't cry" are certainly uncalled-for. If it's benign you got to live with it! The idea, "if it's not cancerous", it won...
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Eat Whole Foods! Lose Weight, Improve Your Blood Lipids, Reduce Estrogen, Protect Yourself Against Chromosomal Damage and Defeat Prostate Cancer With Cabbage.

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Image 1: The magic ingredient is in the root not in the commonly eaten leaves of "bok choy". Chances that you will find a "whole" (including the root) chinese cabbage" (lat. brassica rapa ) at your local supermarket, are yet very low... but wouldn't this be a good reason to start gardening really "whole" foods in your backyard? (img. Wikigardener ) If you are a student of the SuppVersity, you are probably already annoyed by my favorite slogan " Nature knows best! " Nevertheless, I will not tire to repeat that " eating your way to a leaner and healthier you " is probably the only sustainable alternative on a side-effect ridden life on drugs such as Xenical. As Trisha Gura points out in a newsitem on sciencemag.com , [t]he current trio of [weight loss] drugs on the market, endocrinologists say, is, at best, weak and, at worst, plagued by side effects. Hoffmann-La Roche's Xenical, for instance,...
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5α-androstane-3,6,17-trione - Kneller's Trione: Newly Patented Aromatase Inhibitor that Raises Testosterone Without Lowering Estrogen Levels!?

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I happened onto an interesting patent ( Kneller. 2011 ), published on 02/10/2011 the author of which, Bruce Kneller, who was arrested in the course of a steroid bust back in 2006 , claims to have invented an aromatase inhibitor, 5α-androstane-3,6,17-trione (Kneller's Trione) which produces " substantial and significant increases in plasma testosterone levels in men while inducing no changes outside the accepted normal limits for plasma estradiol levels". This is very different from your usual AI (ATD, Arimidex, Letrozole, etc.) which tend to eradicate estrogen and thus produce nasty side effects. As far as its concrete applications are concerned the author writes: The oral, daily dose of Kneller's Trione can be from about 25 mg to about 750 mg per day , such as, for example, from about 25 mg to about 500 mg per day, from about 25 mg to about 250 mg per day, or from about 25 to about 100 mg per day. [...] In some embodiments of the invention the composition c...
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Trigonella foenum graecum Slightly Increases Testosterone, but Fails to Illicit Gains in Lean Body Mass

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A recently published study by Colin Willborn et al. ( Willborn. 2010 ) found that supplementation with 500mg of the purported aromatase inhibitor Trigonella foenum graecum did increase total testosterone +6.57% and bioavailable testosterone +12.26%  over an eight week period. Yet, the ingredient that is part of several commercially sold " muscle builders " did not increase lean body mass in thirty resistance-trained men. Figure 1: Body-fat loss from baseline testing (T1) through Week 8 (T3), mean Delta ± SD. What it did do, however, was to support a reduction in body fat (-2.0%), beyond the one seen in the placebo group (cf. figure 1). This is particularly interesting, because the hormonal data shows that the extract in fact failed to block aromatization effectively; this may be concluded from the fact, that apart from the rise in testosterone, there was a minor increase in estrogen, as well. In view of the lack of strength gains No significant changes were detected amo...
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Impressive Blood Work on Brassaiopsis glomerulata, i.e. DS Triazole. Less Test Boosting Than ATD, Though

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Figure 1: Driven Sports new aromatase inhibitor Triazole This is no typical SuppVersity stuff, because it is an N=1 sponsored "investigation" (meaning: take it with a grain of skepticism) into the effect of a dietary supplement. Nevertheless, I find it interesting enough to post the results a tester of Driven Sports new aromatase inhibitor Triazole posted on a thread of mine on the BB.COM board : Total Test went from 625 to 1032. Free Test went from 74.9 to 148.1. I'm posting from my phone, so I will have to post a copy of the results when I can scan them tonight. __________________ Driven Sports Rep www.getds.com www.drivensports.co.uk If these values aren't fake ( update: scans have been posted here ) this equals an impressive rise of about 65% in total testosterone (less significant in view of muscle gains) and an even more important rise of 98% in free testosterone . Although you certainly won't see similar gains as on an AAS-cycle, the l...
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Brassaiopsis glomerulata: Novel Natural Aromatse Inhibitor in Driven Sports Triazole

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Figure 1: Chemical structure of selected components of Brassaiopsis glumerulata ( Balunas. 2009 ) Now, that the craze about USPs Pink Magic is just abating, a new purported supplement blockbusters from Driven Sports , called Triazole , is already on it's way to the market shelves. It must have been a 2009 study by Bulanas et.al. ( Balunas. 2009 ) which inspired Matthew Cahill and his team to include pZole , a propietary extract of Brassaiopsis glumerulata , in the formula of what they advertise as "the Estrogenic Equalizer". In fact, the results of the aforementioned study are promising. Out of the 13 components the scientists isolated from this shrub of family Araliaceae , no. 9, 10 and 12 (cf. figure 2) appear to be promising candidates for over-the-counter aromatase inhibitor of the year. Figure 2: Aromatase activitity after preparation of hormone-independent human breast cancer cells that overexpress aromatase with selected component from  Brassaiopsis gl...
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