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Why's Maintaining 'Ur Fat Loss so F* Hard? Calorie Counter Will Ramp Up Your Appetite, No Matter What - Lifelong Anti-Weight-Gain Efforts Required in Formerly Obese Subjects

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If  obesity is a chronic disease it cannot be surprising that it cannot be cured and weight loss maintenance requires life-long effort(s) on part of the formerly obese (note: things are different for non-obese individuals trying to shed extra-pounds). I've discussed the issue of "metabolic damage" in a series of previous SuppVersity  articles and pointed out that the scientific evidence supporting the disproportionate down-regulation of your metabolic rate with (significant) weight loss cannot support the exorbitant weight rebound we see in many so-called "weight-reduced individuals", who return to their "normal" dietary habits. Now, a recent study from the US (Polidori. 2016) shows that this weight gain is mostly driven by a hitherto largely overlooked increase in appetite - an increase that goes way beyond any effects of "metabolic damage". High protein helps, but do not counter the weight loss induced changes in RMR & appetit...
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Get Lean & Stay Lean with Emedin, Galangin & Antibiotics. Plus: Breakfast & Morning Glucose Metabolism. Diet Once, Never Eat to Satiety Again? Adipocyte Size & NAFLD

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Instead of making excuses for posting yet another "short news" collection instead of the next installment of the Athlete's Triad series, I will honestly tell you that I simply wasn't in the mood. Moreover, I have the feeling that I have already outlined what is going to work, i.e. train less, eat more and don't get all psyched up about being lean and looking good. Live your life! Against that background my gut tells me that any further details would just get you off track and back into the viscous cycle of overtraining, overdieting and overthinking why things don't work out for you by evoking the impression that as long as you take supplement X you could get away with doing a little bit 'less less' and eat a little bit 'less more'. This would be about as counter-productive as the eternal quest for the ultimate body fat blocker or fat burner of which today's Get lean and Stay Lean Quickie does actually feature three. While the tempora...
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5% Calorie Restriction & Longterm Dieting Make You Fat & Insulin Resistant. Plus: Model Predicts Weight Loss Based On Number of Weight Lost & Diet Pill Use On Previous Diets

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Image 1: "Bikini Body Now!" , headlines like this and the unfair suggestion that by following diet X or taking supplement Y you would make it onto the cover of a magazine like that are part of the problem why diets fail, people get discouraged and caught in the diet trap. The issue of yoyo dieting and the existence and non-existence of a body weight or body fat set-point has been an issue in more than a handful of SuppVersity posts, already ( click here to read more). None of the studies I cited (and not even one of those I have read) did yet provide a conclusive and experimentally verifiable answer to the question whether or not there is such a thing as a "set point" and how or even if dieting influences the latter. What common "wisdom" would suggest, though, is that dieting will ruin your metabolism, so that both the post-dieting weight rebound, as well as future problems with losing weight would be programmed. So the question is: Can you diet...
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Set to Be Obese!? Dopamine Turns Out to Be Another Major Player in the Neurological Orchestra of Obesity

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As I promised, I am trying my best to keep up with current research on the neurological aspects of obesity, I also talked about on Carl Lenore's Super Human Radio on March 31, 2011 . While the focus of the previously mentioned study was on the less well-known relationship between inhibitory and excitatory neurons in the hypothalamus, the major player scientists from the University Medical Center at Leiden in the Netherlands studied is a rather famous one: Dopamine. Figure 1: Basal glucose & insulin levels in DIO & DR mice after 2 weeks on placebo (P), bromocriptine (B) or haloperidol (H) (data adapted from de Leeuw van Weenen. 2011 ) What de Leeuw van Weenen et al ( de Leeuw van Weenen. 2011 ) found in the same diet induced obesity [DIO] mouse model Ravussin ( Ravussin. 2011 )had used in his study (cf. Follow Up on Set-Point Theories: Could Royal Jelly Help With Obesity / Diet Induced Structural Brain Changes? ) were altered dopaminergic transmission exaggerated basa...
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Follow Up on Set-Point Theories: Could Royal Jelly Help With Obesity / Diet Induced Structural Brain Changes?

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The colleagues over at ergo-log.com dug up a 2009 study ( Narita. 2009 ) on the endocrine effects of royal jelly supplementation on rats. You may now wonder "Why is he suddenly beginning to writing off information about old studies on other sites?" Well, my interest in this study relates to my recent appearance on Carl Lenore's Super Human Radio show (I know, I promised a write-up /just have to find the time ;-) and diverges from the original interpretation the anonymous author over at ergo-log provided. As you may have heard on the podcast, the most significant finding of the Ravussin study ( Ravussin. 2011 ) was the down-regulation of pro-opiomelanocortin [ POMC] neurons in the hypothalamus , which went hand in hand with weight gain and weight loss and is associated with a reduction of the metabolic rate to levels at which further weight loss or even weight maintenance become a significant challenge. Here, the findings of the aforementioned study on royal jelly, ...
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ProfDrAndro @ Super Human Radio: Set to Be Obese? Of Set & Settle Points on Your Way to a Super Human Physique

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Just in case you got nothing else to do: Tune in live and listen to some more (probably Carl) or less (probably me ;-) intelligent Supp-Talk on Carl Lenore's Super Human Radio ! Topic: Set & settle points and how contemporary science may contribute & explain your personal weight loss success Update: available for Download now Listen live @ 9:00AM AM/12:00PM ET
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