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Study Identifies Caffeic Acid Induced AMPK-α2 Activity Behind the Fat Burning, Insulin-Sensitizing & Life-Extending Effects of Coffee. Plus: Why Creatine & Coffee Don't Mix!

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Image 1: I've got news for you: Real coffee does not come in brown sterophome cups ;-) Ever since Starbucks came out with the "McDonald's version" of what used to be the drink of the popes and kings, coffee has gotten sort of a bad reputation. It is supposed to "burn out your adrenal glands" (I bet most people who support this hypothesis don't even know where the adrenal glands are situated), derive you of  vital nutrients and water, reduce insulin sensitivity, give you palpitations and high blood pressure, ... I guess, you know the whole litany. If we take a closer look at the contemporary scientific consensus, many of these arguments against your 2-3 cups of coffee per day lack any scientifically verified basis. Others apply only if you (ab-)use the uber-potent high-caffeine, high sugar, low polyphenol Starbucks brew as "rocket fuel" on your mission not to mars, but to your first (or next?) heart attack. Live longer, live leaner and l...
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Intermittent Thoughts On Intermittent Fasting - Exercise (3/3): How Training Solves the AMPK/mTOR Antagonism.

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Image 1: Just like Two-Face , a character from the Batman comic books, AMPK turns out to have two faces,... ah I mean isoforms the differential expression of which explain why exercise, contrary to starving yourself, maintains or even builds muscle mass while reducing your love handles (img batman.wikia.com ). In the last installment of the Intermittent Thoughts on Intermittent Fasting series , we have revisited the idea of different training modalities , i.e. endurance and strength training, for the promotion of AMPK-related reductions in body fat and mTOR-dependent increases in muscle mass. We have also busted the long-standing myth of the "anabolic window of opportunity" , which, upon closer examination, turned out to have the size of a barn door (>24h) that is unlocked with the key of exercise and nutrition sciences. Related findings showed that even in the absence of additional nutritional stimuli a single intense strength training session led to a profound and (...
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