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Science Round-Up Seconds: All About Cortisol, Fat Loss, Body Composition and the Efficacy & Safety of 7-Keto & Co

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Believe it or not. High dose hydrocortisone can decrease body fat levels (Babikian. 1962; see further down) and the acute administration of prednisolone has repeatedly been shown to have pronounced endurance performance (e.g. +61%; Arlettaz. 2007). It's not like the Science Round Up was a request show, but I still want to start the Seconds to yesterday's installment of the show ( download the podcast ) with an honest an sincere apology to one of our listeners. Yeah, there is no debating, Carl and I had promised to talk about the "cortisol blockers can cause necrosis of the liver" study (Zou. 2013) and then simply forgot about it. I guess this was due to the unplanned "copper + HFCS = arrhythmia" excursion at the beginning of the show, but I don't want to give the impression I was looking for excuses here. Instead, I decided to make up for our negligence by taking the opportunity to go beyond simply answering the question whether the recently pub...
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On Short Notice: Ghrelin & GH Boosting Fats for Intermittent Fasting, 4-AD, 5-AA, Testosterone & Co in "Pod", Too Much Vitamin D for Your Prostate, Estrogens in Milk & More

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Image 1 (fidged-group.co.uk): Being average may not be sexy, but one thing I did not mention in the summary of what you are going to learn today is that an average amount of body fat (not the new average American though ;-) could hold the key for a longer life - ah, I almost forgot: This is only valid if it comes with an appropriate amount of lean mass, which is still the best predictor of a long and healthy life! Somehow these On Short Notice posts become increasingly longer... I had to "outsource" a couple of items, to reduce today's installment to a manageable length, but don't worry a couple of them will turn up in the next installment or make it into the regular news in the days to come. For now you will have to settle for valuable and at least in part surprising insights into the broad range of effects different types and loads of dietary fat can have on your appetite, metabolism and your, or rather your bacterial subtenants' methane production . You w...
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DHEA the Slimming Hormone? Study Finds: Dehydroepiandrosterone Directly Inhibits Cortisol Synthesis in Rodent Adipocytes

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After initially being hailed as the fountain of youth, the pharma-financed medical sciences dropped DHEA, when investors realized that a naturally occurring hormone would not be patentable. This and some discouraging and/or inconclusive results from long-term studies had DHEA literally disappear from the research scene for quite some time. Therefore, I am positively surprised that on the forthcoming European Congress of Endocrinology 2011 researchers from the Kobe University in Japan are going to present a paper ( Tagawa. 2011 ) that shows that there may in fact be more to the initial findings of DHEA induced weight loss than follow-up studies would have it. Tagawa et al. investigated the possible mechanism behind the weight loss effects of DHEA and found that there is a direct inhibitory effect of DHEA on glucocorticoid (re-)synthesis in adipose tissue: Using differentiated 3T3-L1 adipocytes, we demonstrated that DHEA inhibited 11β-HSD1 activity at a concentration of 1 μM within...
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Poly-Unsaturated Fatty Acids (PUFA) Alter Glucocorticoid Action on White Adipose Tissue

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A very recent investigation found a possible explanation for the protective effects of high PUFA consumption against adiposity and the metabolic syndrome. On the cellular level, PUFA decreases an enzyme, called 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1), which amplifies intracellular glucocorticoid action by converting inactive glucocorticoids to their active forms in vivo. Figure 1: Effect of Diet high in PUFA, SFA, TFA on enzyme activity (HSD1 basal = 10%). The scientists explain that, in mice, "adipose-specific overexpression of 11beta-HSD1 induces metabolic syndrome [...], whereas 11beta-HSD1 null mice are resistant to it." For the average human being this means avoiding overgeneration of this enzyme may well keep him/her lean. And in fact, the most effective way to do so, is to follow the general advice to avoid trans-fatty acids (TFA) and saturated fatty acids (SFA) and consume polyunsaturated fatty acids (PUFA) instead: 11beta-HSD1 gene expressio...
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