Potratz on SHR: Grape Fruit Oil for Enhanced Oral Steroid Resorption
Just for those of you who are not yet addicted to the Super Human Channel , i.e. Carl Lenore 's radio program on exercise, nutrition and longevity: Wednesday, 15 December 2010, Carl had Eric Potratz from Primordial Performance on the show and talked to him about what could be the future of oral drug/steroid delivery. Although the show certainly smacks of a product pimpjob, the general information Potratz provides is scientifically correct. Audio 1: Super Human Radio - 631 - Oral Hormone Delivery And Bioavailability Potratz main argument that grape fruit blocks the intestinal esterase, i.e. the removing of the ester attached to a steroid to render it absorbable via the lymphatic system, has been confirmed in several studies. More recently, Li et. al. ( Li. 2009 ) reported: [..] oral coadministration of GFJ [Grape Fruit Juice] or an esterase inhibitor, bis-( p -nitrophenylphosphate), with the prodrugs led to respective increases in plasma area under the ...