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Vitamin A (Retinol) & Glucose Management | Part VIII of the "There is More To Glucose Control Than Low Carb"- Series. Plus: Retinol's Effects on Pancreas, Liver, Muscle and Fat

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Vitamin A is not exactly known for being an anti-diabetes vitamin. If anything people will associate it with skin health... and SuppVersity Readers probably with anti-cellulite treatments | learn more In the previous installments of this series I have addressed many of the "usual suspects" everyone associates with non-carbohydrate dependent improvements in blood glucose management. In today's installment of this series I will now take a look at an important vitamin of which only few would expect that it is in any way involved in glucose management: Vitamin A - real, pre-formed retinoic acid, not beta-carotene. In view of the misleading news about the "involvement" of retinol binding proteins in the etiology of the diabesity epidemic and the bullocks about the negative effects of vitamin A on vitamin D, the vast majority of health junkies all over the web will probably associate high vitamin A intakes with insulin resistance, not -sensitivity. You can l...

Epigenetics - From Mother to Child: Retinoid X Receptor-α Methylation "May Explain >25% of the Variance in Childhood Adiposity"

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A few blogposts "ago", I reported the negative influences maternal (over-)nutrition may have on the unborn child . A recent study ( Godfrey. 2011 ) from the University of Southampton provides insights into which detrimental genetic switches underlie a disadvantageous pre-natal metabolic programming, the consequences of which may well be one of the myriad of factors contributing to the global increase in (childhood) obesity. Figure 1: Rise in childhood obesity from 1963-2008 (from CDC.gov ) Godfrey et al. analyzed the methylation status (if a gene is methylated it is turned off) of several genes in the cord blood of newborns from two independent cohorts (cohort 1: 68 samples; cohort 2: 31 samples) and found that [i]n cohort 1, retinoid X receptor-α (RXRA) chr9:136355885+ and endothelial nitric oxide synthase (eNOS) chr7:150315553+ methylation had independent associations with sex-adjusted childhood fat mass (exponentiated regression coefficient [β] 17% per SD change i...
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