Antioxidant Gear: Anabolic Steroid Stanozolol Decreases Mitochondrial ROS Generation and Oxidative Stress Induced by Acute Exercise in Rat Skeletal Muscle
Figure 1: Molecular structure of Stanozolol (from Wikipedia) Oswaldosalcedo, a member of the Mind&Muscle forum came up with a recent study ( Saborido. 2011 ) that found some surprisingly healthy "side-effects" of Stanozolol , a synthetic anabolic orally available steroid derived from testosterone, also known as Winstrol . The scientists tested the effect of Stanozolol administration on markers of mitochondrial oxidative stress in rats after an acute bout of exhaustive exercise and found: Stanozolol treatment markedly reduced the extent of exercise-induced oxidative damage to mitochondrial proteins, as indicated by the lower levels of the specific markers of protein oxidation, glycoxidation, and lipoxidation, and the preservation of the activity of the superoxide-sensitive enzyme aconitase. This effect was not due to an enhancement of antioxidant enzyme activities . Acute exercise provoked changes in mitochondrial membrane fatty acid composition characteri...