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HMB Increases Lean Mass Loss (+22%) + Hampers Fat Loss (-18%) from Diet + Overtraining. HED of ~6g/Day Does Yet Retain Muscle Strength & Fiber Size in Fast Twitch Muscles

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Dr. Jekyll & Mr. Hyde - Is HMB have another janus-faced supplement ? I know "mice are no little men", ... I don't have to be reminded of that. Thank you. So, if you are not interested in today's SuppVersity article, just come back tomorrow for another article without our hairy friends in it... You are still here? Ok, then let's see what the researchers at the Florida State University have to tell us about the effects of HMB supplementation on trained vs.  overtrained and energy deprived rodents. Even though, the significance of the results for mammals with less body hair such as human beings is not clear, we may still expect similar trends, yet not identical numbers on the weight, muscle and fat loss, as well as parameters that were assessed in the study at hand. Some details on the experimental protocol The scientists started out with a total of 61 animals that were initially divided into three groups. The animals in the groups were either sedentary...
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HMB Exhibits Differential Effects on ATP and Glycogen Content of Fast & Slow Twitch Fibers and Maximizes Tetanic Force Development in Rodent Study

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Image 1: This is where HMB could actually make a difference, the two more reps, the one more sprint, which after weeks and months of training can decide over victory or defeat. Sometimes, or I should say, time and again (!), it amazes me how the same people who are willing to invest hundreds of bucks in a supplement, which (according to the patent holder) "has been shown in scientitfic studies" (which were conducted by the researcher and a buddy of his at a remote lab, only to file the patent) to " increase testosterone by up to 147.34% ", keep telling me that they "would never waste their hard earned money on supplements like HMB... " hello? Am I missing something, here? I mean, right; HMB does not produce the steroid-like effects the same sort of shady businessmen who are now promoting a new natural testosterone booster as legal alternative to Anavar on a monthly base once claimed it would have, but in all  honesty, the scientific research on HMB is ...
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More Conflicting Evidence on Leucine Metabolite: HMB Makes Volleyballers Stronger.

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The leucine metabolite HMB, i.e. β-Hydroxy-β-Methylbutyric acid , is unquestionable the comeback kid of the supplement industry. "It works!", "It's useless!", ... every now and then a new study supports one side of the debate. A group of international scientists does now present a study, which would support the use of the expensive, yet readily available amino acid. Portal et al. ( Portal. 2011 ) investigated the effect of 3g HMB/day "on body composition , muscle strength , anaerobic and aerobic capacity , anabolic/catabolic hormones and inflammatory mediators in elite, national team level adolescent volleyball players (13.5–18 years, 14 males, 14 females, Tanner stage 4–5) during the first 7 weeks of the training season". The results were unequivocal, yet not overtly impressive: HMB led to a significant greater increase in FFM by skinfold thickness (56.4 ± 10.2 to 56.3 ± 8.6 vs. 59.3 ±  11.3 to 61.6 ± 11.3 kg in the control and HM...
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Beta-Hydroxy-Beta Methylbutyrate Strikes Back: HMB Increases GH and IGF-1 at the Expense of Insulin Resistance

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"HMB" - do you remember these three letters? If you have been around the supplement world in the early 2000s, you probably will. Beta-hydroxy-beta methylbutyrate ( HMβ ) is a metabolite of leucine which has been advertised to enhance exercise performance, reduce fatigue and promote muscle gains. Nothing of that has been substantiated within larger human studies, though; and thus HMB a former star among the amino acid supplements has almost been forgotten. Now, a recent study from Brazil ( Gerlinger-Romero. 2011 ) provides data suggesting that HMB may in effect raise the content of pituitary GH mRNA and growth hormone [GH], as well as hepatic IGF-I mRNA and serum IGF-I concentrations. It was observed that the HMβ treatment induced an increase in GH mRNA by 65% (P < 0.001) and in GH content by 20% (P < 0.05) compared to control group. The IGF-I mRNA expression in liver, as well as the serum IGF-I concentration was also significantly increased in the HM...
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Study Indicates Uselessness of HMB-Supplementation

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Figure 1: Molecular structure of HMB (HMDB v2.5) In view of the fact that the educated gymrat will already have known this for years, it is hardly worth being cited that scientists ( Slater. 2010 ) provide further evidence for the ineffectiveness of oral HMB supplementation in the latest issue of the International Journal of Sports Nutrition & Exercise Metabolism . None of the variables the scientists measured (body mass, body composition - using dual energy x-ray absorptiometry, and 3-repetition maximum isoinertial strength, markers of muscle damage and muscle protein turnover), was influenced by supplementing 3g HMB per day: While the training and dietary intervention of the investigation resulted in significant strength gains (p < .001) and an increase in total lean mass (p = .01), HMB administration had no influence on these variables . Likewise, biochemical markers of muscle protein turnover and muscle damage were also unaffected by HMB supplementation. In vi...
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Getting Old? Try Some HMB Against Loss of Lean Body Mass

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While the effectiveness of the leucine metabolite b-hydroxy-b-methylbutyrate (HMB) in athletes is debatable, its usefulness in geriatric scenarios becomes more and more obvious. On July, 2 2010, Kim et.al. ( Kim. 2010 ) presented the results of a study investigating the effect of HMB (0.46 g/kg/d, similar to 6 g/d in humans) to old rats for 16 wks prior to being sacrificed. The beneficial effects on the retention of lean body mass speak for themselves: "The LBM decline from 60 to 102 wks was only observed in the Non-HMB group (p<0.05). There was a main group x time effect (p<0.01) in the lean/total body mass (LBM/TBM) ratio, indicating an improved ratio only in the HMB group between 86 and 102 wks (+35%). A group x time effect in fat mass (FM, g) revealed a significant loss in FM (-55%) only in the HMB group between 86 and 102 wks (p<0.01)." ( Kim. 2010 ) The reason why I mention these results on a blog directed mainly to athletes and younger people is that...
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