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Science Round-Up Seconds: All About Cortisol, Fat Loss, Body Composition and the Efficacy & Safety of 7-Keto & Co

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Believe it or not. High dose hydrocortisone can decrease body fat levels (Babikian. 1962; see further down) and the acute administration of prednisolone has repeatedly been shown to have pronounced endurance performance (e.g. +61%; Arlettaz. 2007). It's not like the Science Round Up was a request show, but I still want to start the Seconds to yesterday's installment of the show ( download the podcast ) with an honest an sincere apology to one of our listeners. Yeah, there is no debating, Carl and I had promised to talk about the "cortisol blockers can cause necrosis of the liver" study (Zou. 2013) and then simply forgot about it. I guess this was due to the unplanned "copper + HFCS = arrhythmia" excursion at the beginning of the show, but I don't want to give the impression I was looking for excuses here. Instead, I decided to make up for our negligence by taking the opportunity to go beyond simply answering the question whether the recently pub...

DHEA: Overlooked or Overrated?

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With DHEA (structure of DHEA-S, see image on the right; HMDB. V2.5 ) having been mentioned in a few of the last posts as a precursor to other androgens, I thought it might be interesting to have a brief look at the effect of DHEA supplementation on mood, body composition, sex life and human endocrine balance. Lately, a 1988 study by Nestler et.al. ( Nestler. 1988 ) has caught my attention. The researchers investigated the effect of 28 days of 1600mg/day (no, this is no typo) orally supplemented DHEA in 5 normal men (+5 men on placebo). The results were simply amazing. Apart from a 2.5x-3.5x increase in DHEA-levels, the researchers found: "In the DHEA group the mean percent body fat decreased by 31% , with no change in weight. This suggests that the reduction in fat mass was coupled with an increase in muscle mass ." ( Nestler. 1988 ) In addition mean serum low density lipoprotein cholesterol decreased by 7.5% (3.21 +/- 0.11 vs. 2.97 +/- 0.14 nmol/L; P less than 0.01...
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