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Role of Muscle and CNS in Diet-Induced Decline of Exercise-Induced Energy Expenditure | Caffeine & Nicotine May Help!

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While "calories count" when it comes to losing body fat, the notion that you would always burn the same amount of energy with a given workout - irrespective of your energy intake - is completely bogus and only one of the reasons why meticulous calorie counting won't work.  Let's address it right away: Yes, the paper Tariq I. Almundarij et al. published in the peer-reviewed journal "Physiological Reports" (Almundarij 2017) deals with a rodent experiment, but  with the goal of the study being to identify the fundamental mechanisms behind, not the extent of metabolic adaptation to calorically reduced energy intakes, this does not disqualify its results as irrelevant for humans - on the contrary (and trust me, I'd prefer a human or at least a pig study, too). With that being said, let's take a look at what the scientists did to "investigate the role of MC4R in the modulation of muscle work efficiency, and test the hypothesis that energy restri...

Follow Up on Set-Point Theories: Could Royal Jelly Help With Obesity / Diet Induced Structural Brain Changes?

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The colleagues over at ergo-log.com dug up a 2009 study ( Narita. 2009 ) on the endocrine effects of royal jelly supplementation on rats. You may now wonder "Why is he suddenly beginning to writing off information about old studies on other sites?" Well, my interest in this study relates to my recent appearance on Carl Lenore's Super Human Radio show (I know, I promised a write-up /just have to find the time ;-) and diverges from the original interpretation the anonymous author over at ergo-log provided. As you may have heard on the podcast, the most significant finding of the Ravussin study ( Ravussin. 2011 ) was the down-regulation of pro-opiomelanocortin [ POMC] neurons in the hypothalamus , which went hand in hand with weight gain and weight loss and is associated with a reduction of the metabolic rate to levels at which further weight loss or even weight maintenance become a significant challenge. Here, the findings of the aforementioned study on royal jelly, ...
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