Ask Dr. Andro: What Are Human Equivalent Doses (HED) and How Do I Calculate Them?
Image 1: Rat & guinea pig. Both very popular animal models. Both about the same size and weight, but with very different reactions to identical treatments. I won't waste too many words on this being a new series on the SuppVersity , I suppose the name "Ask Dr. Andro" is self-explanatory. It is based on questions posted in the comment section that are relevant for the majority of the visitors and require and deserve a more sophisticated response. So, if you want your question answered, learn a lesson from "Learner" who posted the following question in the comment section of " Spicing Up Fat Loss: Structural Similarity to Melanocortin-4 Agonists Powers Piperine's (Black Pepper Extract) Fat Loss and Lipid Lowering Effects ". Question from "Learner" : Why is the mg/kg dosing ratio different for humans than rats, and does that vary by the agent? Answer from Dr. Andro : Most of what we know about the effects of (new) drugs, ...