Melatonin As Potent as Letrozole in Inhibiting Aromatization of Testosterone to Estrogen - This Raises the Question: Is a Lack of / Bad Sleep to Blame for Breast Cancer?!
|Sleeping for 7-8h w/out interruption in a pitch black room to max. your melatonin is the best breast cancer prevention.|
The latter increases in women who do not sleep during the period of the night when melatonin levels are typically at their highest by ~14% (Davis. 2011), an observation that appears only logical in view of what I am about to tell you today.
You can learn more about sleep and the circadian rhythm at the SuppVersity
These previous observations were the actual reason why Suthat Chottanap and colleages set up a handful of petri-dishes in which they a co-culture model primary human breast adipose fibroblasts (BAFs) with testosterone and melatonin or resveratrol. It has long been known that these fat cells from the breast tissue can convert testosterone to estradiol, and do thus contribute to the estrogen receptor-mediated growth and proliferation of of breast cancer T47D cell proliferation.
|Figure 1: Anti-aromatase effect of resveratrol vs. melatonin (1000x lower dosage; left) and anti-proliferative (=anti-growth) effects of melatonin in breast cancer cells (Chottanapund. 2014)|
- for resvertrol the scientists needed a concentration of 20µM, i.e. 20 microMol = 0.000002 Mol and thus 1000x more(!) than for melatonin
- for meltonin a concentration of 20nM, i.e. 20 nanoMol = 0.000000002 Mol was sufficient
What really makes the results outstanding, though, is that melatonin was as potent as letrozole, the most potent antiaromatase inhibitor the publicly available pharmaceutical arsenal knows in suppressing cell proliferation, estradiol (E2) production and gene expression of CYP19A1, pS2andKi-67. No wonder that the Thai authors of the paper at hand are convinced that "melatonin clearly offers potential advantages for breast cancer treatment". And this assumption is supported by both the often-reported association between increased breast cancer risk and shift work and the inverse correlation between the risk of breast cancer and urinary melatonin levels Eva S. Schernhammer and Susan E. Hankinson report in a 2005 paper - a correlation, which remained significant even when the women who had a history of night-shift were excluded!
|Learn how light synchronizes your circadian rhythm and protects you against breast cancer & obesity.|
While we are waiting for the first rodent and human studies to confirm a systemic anti-aromatase effect of melatonin, I would thus suggest that you take another look at the SuppVersity Circadian Rhythm Series, all the articles of which you can find @ http://suppversity.blogspot.com/feeds/posts/summary/-/crs/?max-results=9999 if you are using an RSS compatbile browser or a plugin for chrome.
- Chottanapund, Suthat, et al. "Anti-aromatase effect of resveratrol and melatonin on hormonal positive breast cancer cells co-cultured with breast adipose fibroblasts." Toxicology in Vitro (2014).
- Davis, Scott, Dana K. Mirick, and Richard G. Stevens. "Night shift work, light at night, and risk of breast cancer." Journal of the national cancer institute 93.20 (2001): 1557-1562.
- Schernhammer, Eva S., and Susan E. Hankinson. "Urinary melatonin levels and breast cancer risk." Journal of the National Cancer Institute 97.14 (2005): 1084-1087.