|Image 1: Transverse section of a tubule of the testis of a rat. X 250. (Wikipedia)|
The latter is especially true in view of conflicting data on the effects of vitamin D on aromatase activity in especially in view of previous studies such as Lundgvist 2011 et al. (Lundgvist. 2011) who found that
In breast cancer MCF-7 cells, aromatase gene expression and estradiol production were decreased, while production of androgens was markedly increased. In NCI-H295R cells, 1α,25-dihydroxyvitamin D(3) stimulated aromatase expression and decreased dihydrotestosterone production. In prostate cancer LNCaP cells, aromatase expression increased after the same treatment, as did production of testosterone and dihydrotestosterone. In summary, our data show that 1α,25-dihydroxyvitamin D(3) exerts tissue-specific effects on estrogen and androgen production and metabolism.So, will taking supplemental Vitamin D3 (1,25D) transform you into a hermaphrodite? Will you get rid of gynecomastia (gyno), but develop testicular cancer? The answer to both questions is probably "NO" And I am by no means suggesting that you extrapolate the rat data from isolated sertoli cells to human beings, but In view of these findings, it is nevertheless becoming increasingly questionable whether the correlations between testosterone and vitamin D that have been observed in epidemiological studies have not been misinterpreted as causative, where in fact, both, higher testosterone, as well as vitamin D levels, are a mere results of confounding variables such as an overall healthier, more active lifestyle. After all, our previous understanding of the connection between vitamin D and testosterone could have been as misleading as the idea that firetrucks cause fire, because an "epidemiological" investigation of fires would show that they are present whenever ones breaks out.
Video 1: Clifford L. Johnson, MSPH (CDC):
"The Importance of Monitoring Vitamin D Status in the U.S.",
Thursday, August 19, 2010, at 9 a.m. (EDT)
A pros pos epidemiological studies: A recent report from the Centers for Disease Control and Prevention National Center for Health Statistics in Maryland (see video above) states that in the US...
[t]he risk of vitamin D deficiency increased between 1988-1994 and 2001-2002 in both sexes but did not change between 2001-2002 and 2005-2006.With two-thirds of the population having, what the National Center for Disease Control and Prevention considers "sufficient vitamin D" levels, you probably better follow my previous advice and just get your level tested before starting on any kind of supplementation regime. If you want to do me a favor, you also check how taking additional D affects your testosterone levels. I promise to publish your results - anonymously, of course ;-)