|Image 1: "Wendy" myostatin negative dog|
and 7 months old baby of a 24-year old
female former athlete with a family
history of "particular" strength
(image "baby" from Schuelke. 2004)
Before the yeast was administered to the mice at a weekly dose of 120,000,000 yeast cells for 5 weeks, Zhang et al. had cultured the yeast with copper sulfate for 10h to induce the expression of myostatin and ovo-myostatin proteins.
|Figure 1: Increases in body weight of 5-week old Kunming mice after 5 weeks of oral or intravenous treatment with recombinant yeast cells (calculated based on data from Zhang. 2011).|
|Figure 2: Additional muscle gain measured in forelimb, hindlimb muscles, as well as triceps brachii and biceps femoris compared to control in 5-week old Kunming mice after 5 weeks of oral or intravenous treatment with recombinant myostatin or ova-myostatin yeast cells (calculated based on data from Zhang. 2011).|
In this study, immunized mice in all groups were found generally healthy looking and no signiﬁcant damage in any internal organs. [If one also takes into account the report on the "myostatin baby" by Schuelke et al. (Schuelke. 2004)] these ﬁndings suggest that immuomodulation of myostatin is safe in both laboratory animals and human.
|Image 2: While the mice did gain significant|
amounts of weight (esp. muscle) they are
completely healthy and do by no means
look as bulky as genetically modified dogs,
bulls and co. (image from Zhang. 2011).