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Image 1: "Wendy" myostatin negative dog
and 7 months old baby of a 24-year old
female former athlete with a family
history of "particular" strength
(image "baby" from Schuelke. 2004) |
You have seen those images of myostatin-negative bulls, mice and dogs.
Those ugly overmuscled creatures, who cannot even carry the weight of
their own musculature. Notwithstanding, you were fascinated by the idea
that
myostatin blockers, i.e. drugs that inhibit the growth and
differentiation factor 8 (GDF8), would turn you into lean, mean
mass-monster, but the only results you could find in reliable source were disappointing? Well, you may
then get even more excited, when the reliable source your are just studying is telling you
that "we are finally there"! Scientists from the
Shaan’xi Key Laboratory
of Molecular Biology for Agriculture at the
Northwest A&F University in Shaan’xi, China have found a way to selectively increase muscle weight in mice by oral administration of a whole recombinant yeast
Saccharomyces cerevisiae vaccine (
Zhang. 2011).
Before the yeast was administered to the mice at a
weekly dose of 120,000,000 yeast cells for 5 weeks,
Zhang et al. had cultured the yeast with copper sulfate for 10h to
induce the expression of myostatin and ovo-myostatin proteins.
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| Figure 1: Increases in body weight of 5-week old Kunming mice after 5
weeks of oral or intravenous treatment with recombinant yeast cells (calculated based on data from Zhang. 2011). |
As the data in figure 1 goes to show, the
oral "immunization" procedure turned out
to be more effective than the scientists had even hoped for. Still,
vaccination by injection was 7% and 9% more growth promoting for the
myostatin (MSTN) and ovo-myostatin (Ovo-MSTN) yeast, respectively.
 |
| Figure 2: Additional muscle gain measured in forelimb, hindlimb muscles, as well as triceps brachii and biceps femoris compared to control in 5-week old Kunming mice after 5
weeks of oral or intravenous treatment with recombinant myostatin or ova-myostatin yeast cells (calculated based on data from Zhang. 2011). |
In view of both agricultural applications, as well as legal and illegal performance enhancement in recreational and professional athletes, the most important finding of the study
yet turns out to be a null-finding: Null, that is the number of
pathological change the scientists observed in the course of the study - no abnormal organ growth, muscle weakness and all the other ailments myostatin-null mice, bulls, dogs and whatever poor animals scientists have hitherto genetically modified, usually suffer from:
In this study, immunized mice in all groups were found generally healthy looking and no significant damage in any internal organs. [If one also takes into account the report on the "myostatin baby" by Schuelke et al. (Schuelke. 2004)] these findings suggest that immuomodulation of myostatin is safe in both laboratory animals and human.
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Image 2: While the mice did gain significant
amounts of weight (esp. muscle) they are
completely healthy and do by no means
look as bulky as genetically modified dogs,
bulls and co. (image from Zhang. 2011). |
If you look at the mice in image 2, it is in fact hard to tell, which of the mice received the control and which the myostatin yeast and that despite the fact, that - assuming similar effects in adolescent human beings - the
average sleeve size of humans who have been immunized with this yeast would increase from ca. 32cm to ca. 43cm! That being said, it is unlikely that the "immunization", which has your body produce antibodies against myostatin and thus blocks the inhibitory effect of the TGF beta protein on muscle growth, will produce such profound results in adults, whose bodies obviously are not primed to growth in the way the bodies of children or adolescents are... but hey, there are enough aspiring young athletes in the Chinese Olympic Team to see preliminary results in 2012 (hoops, I think this was not 100% politically correct ;o)
